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    grx2 glutaredoxin Grx2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542807, updated on 18-Sep-2024

    Summary

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    Official Symbol
    grx2
    Official Full Name
    glutaredoxin Grx2
    Primary source
    PomBase:SPAC15E1.09
    Locus tag
    SPOM_SPAC15E1.09
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See grx2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (3731149..3732340)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene NatA N-acetyltransferase complex catalytic subunit Naa10 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PI31 proteasome inhibitor domain-containing protein Neighboring gene GMP synthase Gua2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Carbon source-dependent regulation of a second gene encoding glutaredoxin from the fission yeast Schizosaccharomyces pombe. Kim HG, et al. Mol Biol Rep, 2005 Mar. PMID 15865206
    2. Localization and function of three monothiol glutaredoxins in Schizosaccharomyces pombe. Chung WH, et al. Biochem Biophys Res Commun, 2005 May 6. PMID 15796926
    3. Differential expression and role of two dithiol glutaredoxins Grx1 and Grx2 in Schizosaccharomyces pombe. Chung WH, et al. Biochem Biophys Res Commun, 2004 Sep 3. PMID 15358115
    4. Monothiol glutaredoxin Grx5 interacts with Fe-S scaffold proteins Isa1 and Isa2 and supports Fe-S assembly and DNA integrity in mitochondria of fission yeast. Kim KD, et al. Biochem Biophys Res Commun, 2010 Feb 12. PMID 20085751
    5. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Grx2 protein, located in the nucleus, is linked with the yeast growth, and that the gene is regulated by carbon sources.
      Title: Carbon source-dependent regulation of a second gene encoding glutaredoxin from the fission yeast Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables glutathione disulfide oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione disulfide oxidoreductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glutathione peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-disulfide reductase activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in removal of superoxide radicals IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutaredoxin Grx2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3731149..3732340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019733.3 → NP_594310.1  glutaredoxin Grx2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594310.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UTI2
      Conserved Domains (1) summary
      cd03419
      Location:17 → 98
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
    Nucleotide Protein
    Heading Accession and Version

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