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    swi1 replication fork protection complex subunit Swi1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540728, updated on 18-Sep-2024

    Summary

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    Official Symbol
    swi1
    Official Full Name
    replication fork protection complex subunit Swi1
    Primary source
    PomBase:SPBC216.06c
    Locus tag
    SPOM_SPBC216.06C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See swi1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (907370..914779, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene peptide-methionine (R)-S-oxide reductase Mxr2 Neighboring gene ATR checkpoint kinase Rad3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TORC1 serine/threonine protein kinase Tor2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. swi1- and swi3-dependent and independent replication fork arrest at the ribosomal DNA of Schizosaccharomyces pombe. Krings G, et al. Proc Natl Acad Sci U S A, 2004 Sep 28. PMID 15371597, Free PMC Article
    2. Recombination at DNA replication fork barriers is not universal and is differentially regulated by Swi1. Pryce DW, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19273851, Free PMC Article
    3. Biochemical interactions between proteins and mat1 cis-acting sequences required for imprinting in fission yeast. Lee BS, et al. Mol Cell Biol, 2004 Nov. PMID 15509785, Free PMC Article
    4. DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase. Sabouri N, et al. Genes Dev, 2012 Mar 15. PMID 22426534, Free PMC Article
    5. Swi1 associates with chromatin through the DDT domain and recruits Swi3 to preserve genomic integrity. Noguchi C, et al. PLoS One, 2012. PMID 22952839, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that Swi1 ensures telomere replication by suppressing recombination and repeat instability at telomeres. Our studies may also be relevant in understanding the potential role of Swi1 in regulation of telomere stability in cancer cells
      Title: Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres.
    2. Swi1 associates with chromatin through its DDT domain and recruits Swi3 to function together as the replication fork protection complex
      Title: Swi1 associates with chromatin through the DDT domain and recruits Swi3 to preserve genomic integrity.
    3. Fission yeast Swi1-Swi3 complex facilitates DNA binding of Mrc1.
      Title: Fission yeast Swi1-Swi3 complex facilitates DNA binding of Mrc1.
    4. Swi1, the TIMELESS homologue, differentially controls the recombination potential of replication fork barriers, switching between being a suppressor and an activator of recombination in a site-specific fashion.
      Title: Recombination at DNA replication fork barriers is not universal and is differentially regulated by Swi1.
    5. RFC(Ctf18) and the Swi1-Swi3 complex function in separate and redundant pathways essential for replication fork stabilization to facilitate sister chromatid cohesion in fission yeast.
      Title: RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe.
    6. Hsk1-Dfp1/Him1 and Swi1-Swi3 complexes have interrelated roles in stabilization of arrested replication forks
      Title: Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex.
    7. Swi1, Swi3, and Hsk1 act in a novel S-phase checkpoint pathway that contributes to replication fork maintenance and to survival of alkylation damage.
      Title: Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage.
    8. Results support the notion that Swi1p and Swi3p act at several different protein-DNA complexes in the rDNA spacer regions to arrest replication but that not all fork barriers require their activity to arrest forks. [swi1]
      Title: swi1- and swi3-dependent and independent replication fork arrest at the ribosomal DNA of Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Y-form DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gene conversion at mating-type locus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork arrest IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork arrest IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork arrest at mating type locus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of replication fork protection complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of replication fork protection complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    replication fork protection complex subunit Swi1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      907370..914779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021265.3 → NP_595358.1  replication fork protection complex subunit Swi1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595358.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UUM2, Q9Y7X0
      Conserved Domains (2) summary
      pfam05029
      Location:595 → 956
      TIMELESS_C; Timeless protein C terminal region
      pfam04821
      Location:26 → 278
      TIMELESS; Timeless protein
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials