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    paf1 RNA polymerase II-associated Paf1 complex protein [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543560, updated on 18-Sep-2024

    Summary

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    Official Symbol
    paf1
    Official Full Name
    RNA polymerase II-associated Paf1 complex protein
    Primary source
    PomBase:SPAC664.03
    Locus tag
    SPOM_SPAC664.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See paf1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (1708782..1710347)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene Ino80 complex actin-like protein Arp8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein uS9 Neighboring gene 60S ribosomal protein eL13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inheritance of a Phenotypically Neutral Epimutation Evokes Gene Silencing in Later Generations. Duempelmann L, et al. Mol Cell, 2019 May 2. PMID 30898439, Free PMC Article
    2. The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states. Murawska M, et al. Cell Rep, 2021 Nov 2. PMID 34731638, Free PMC Article
    3. TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres. Cohen A, et al. J Biol Chem, 2018 May 25. PMID 29632066, Free PMC Article
    4. Spt5 Phosphorylation and the Rtf1 Plus3 Domain Promote Rtf1 Function through Distinct Mechanisms. Chen JJ, et al. Mol Cell Biol, 2020 Jul 14. PMID 32366382, Free PMC Article
    5. The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1. Flury V, et al. Mol Cell, 2017 Jul 20. PMID 28648780, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heterochromatin boundary formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cdc73/Paf1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cdc73/Paf1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    RNA polymerase II-associated Paf1 complex protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1708782..1710347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018884.3 → NP_593451.2  RNA polymerase II-associated Paf1 complex protein [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593451.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9US06
      Conserved Domains (1) summary
      pfam03985
      Location:7 → 430
      Paf1; Paf1
    Nucleotide Protein
    Heading Accession and Version

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