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    HER2 glutamyl-tRNA(Gln) amidotransferase subunit HER2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855338, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HER2
    Official Full Name
    glutamyl-tRNA(Gln) amidotransferase subunit HER2
    Primary source
    SGD:S000004907
    Locus tag
    YMR293C
    See related
    AllianceGenome:SGD:S000004907; FungiDB:YMR293C; VEuPathDB:YMR293C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GEP6; QRS1; RRG6
    Summary
    Enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Involved in endoplasmic reticulum organization and glutaminyl-tRNAGln biosynthesis via transamidation. Located in mitochondrion. Part of glutamyl-tRNA(Gln) amidotransferase complex. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 40. Orthologous to human QRSL1 (glutaminyl-tRNA amidotransferase subunit QRSL1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HER2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (855399..856793, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene protein kinase TDA1 Neighboring gene Got1p Neighboring gene Jnm1p Neighboring gene Gsr1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pathogenic variants in glutamyl-tRNA(Gln) amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder. Friederich MW, et al. Nat Commun, 2018 Oct 3. PMID 30283131, Free PMC Article
    2. Characterization of Gtf1p, the connector subunit of yeast mitochondrial tRNA-dependent amidotransferase. Barros MH, et al. J Biol Chem, 2011 Sep 23. PMID 21799017, Free PMC Article
    3. Partial suppression of the respiratory defect of qrs1/her2 glutamyl-tRNA amidotransferase mutants by overexpression of the mitochondrial pentatricopeptide Msc6p. Moda BS, et al. Curr Genet, 2016 Aug. PMID 26780366
    4. Her2p molecular modeling, mutant analysis and intramitochondrial localization. Ferreira-Júnior JR, et al. Fungal Genet Biol, 2013 Nov. PMID 23850602
    5. Crystal structure of Saccharomyces cerevisiae mitochondrial GatFAB reveals a novel subunit assembly in tRNA-dependent amidotransferases. Araiso Y, et al. Nucleic Acids Res, 2014 May. PMID 24692665, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The crystal structure of yeast mitochondrial GatFAB complex.
      Title: Crystal structure of Saccharomyces cerevisiae mitochondrial GatFAB reveals a novel subunit assembly in tRNA-dependent amidotransferases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glutaminyl-tRNAGln biosynthesis via transamidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutaminyl-tRNAGln biosynthesis via transamidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glutaminyl-tRNAGln biosynthesis via transamidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of glutamyl-tRNA(Gln) amidotransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glutamyl-tRNA(Gln) amidotransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of glutamyl-tRNA(Gln) amidotransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutamyl-tRNA(Gln) amidotransferase subunit HER2
    NP_014021.1
    • Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      855399..856793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182801.1 → NP_014021.1  TPA: glutamyl-tRNA(Gln) amidotransferase subunit HER2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014021.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0C0, Q03557
      UniProtKB/TrEMBL
      B3LMI1, B5VQ60
      Conserved Domains (1) summary
      TIGR00132
      Location:1 → 464
      gatA; aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, A subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03557.1

    Gene LinkOut

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