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    ubc4 ubiquitin-conjugating enzyme Ubc4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540083, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ubc4
    Official Full Name
    ubiquitin-conjugating enzyme Ubc4
    Primary source
    PomBase:SPBC119.02
    Locus tag
    SPOM_SPBC119.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    ubcP1
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    Genomic context

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    See ubc4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (715285..716311)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene 19S proteasome regulatory subunit Rpn3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Trp Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene catechol O-methyltransferase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mapping epigenetic mutations in fission yeast using whole-genome next-generation sequencing. Irvine DV, et al. Genome Res, 2009 Jun. PMID 19423874, Free PMC Article
    2. Domain alternation and active site remodeling are conserved structural features of ubiquitin E1. Lv Z, et al. J Biol Chem, 2017 Jul 21. PMID 28572513, Free PMC Article
    3. Two ubiquitin-conjugating enzymes, UbcP1/Ubc4 and UbcP4/Ubc11, have distinct functions for ubiquitination of mitotic cyclin. Seino H, et al. Mol Cell Biol, 2003 May. PMID 12724408, Free PMC Article
    4. A ubiquitin-conjugating enzyme in fission yeast that is essential for the onset of anaphase in mitosis. Osaka F, et al. Mol Cell Biol, 1997 Jun. PMID 9154838, Free PMC Article
    5. BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases. Geyer R, et al. Mol Cell, 2003 Sep. PMID 14527422

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nuclear protein quality is regulated by the ubiquitin-proteasome system through the activity of Ubc4 and San1 in fission yeast.
      Title: Nuclear protein quality is regulated by the ubiquitin-proteasome system through the activity of Ubc4 and San1 in fission yeast.
    2. By this procedure, study identified a weak allele of ubc4, which encodes an essential E2 ubiquitin ligase, as responsible for the swi*603 mutant phenotype.
      Title: Mapping epigenetic mutations in fission yeast using whole-genome next-generation sequencing.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in SREBP signaling pathway EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in SREBP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic metaphase/anaphase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme Ubc4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      715285..716311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021190.3 → NP_595283.1  ubiquitin-conjugating enzyme Ubc4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595283.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P46595
      Conserved Domains (2) summary
      COG5078
      Location:1 → 147
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cl00154
      Location:1 → 146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein
    Heading Accession and Version

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