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    PCC1 chromatin DNA-binding EKC/KEOPS complex subunit PCC1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 1500489, updated on 4-Jan-2025

    Summary

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    Official Symbol
    PCC1
    Official Full Name
    chromatin DNA-binding EKC/KEOPS complex subunit PCC1
    Primary source
    SGD:S000028512
    Locus tag
    YKR095W-A
    See related
    AllianceGenome:SGD:S000028512; FungiDB:YKR095W-A; VEuPathDB:YKR095W-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables chromatin DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; tRNA threonylcarbamoyladenosine metabolic process; and telomere maintenance via recombination. Located in chromatin. Part of EKC/KEOPS complex. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 2. Orthologous to human LAGE3 (L antigen family member 3). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See PCC1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    2
    Sequence:
    Chromosome: XI; NC_001143.9 (625864..626205)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ubiquitin-ribosomal 60S subunit protein L40B fusion protein Neighboring gene Mlp1p Neighboring gene Esl2p Neighboring gene phosphoenolpyruvate carboxykinase PCK1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis. Wan LC, et al. Nucleic Acids Res, 2016 Aug 19. PMID 27302132, Free PMC Article
    2. Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex. Zhang W, et al. Nucleic Acids Res, 2015 Mar 31. PMID 25735745, Free PMC Article
    3. In vitro biosynthesis of a universal t6A tRNA modification in Archaea and Eukarya. Perrochia L, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23258706, Free PMC Article
    4. Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. Wan LC, et al. Nucleic Acids Res, 2013 Jul. PMID 23620299, Free PMC Article
    5. Yeast KEOPS complex regulates telomere length independently of its t(6)A modification function. Liu YY, et al. J Genet Genomics, 2018 May 20. PMID 29804714

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We found that Gon7 forms a stable heterodimer with Pcc1 and report the crystal structure of the Pcc1-Gon7 heterodimer.
      Title: Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex.
    2. EKC/KEOPS complex is specifically involved in the regulation of Bud9p localization downstream of Rax1p/Rax2p.
      Title: Cell polarity in Saccharomyces cerevisiae depends on proper localization of the Bud9 landmark protein by the EKC/KEOPS complex.
    3. We have isolated a new yeast gene (PCC1) that codes for a factor homologous to human cancer-testis antigens.Pcc1p is a new transcription factor and that its mutation affects expression of several genes
      Title: Yeast homolog of a cancer-testis antigen defines a new transcription complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA threonylcarbamoyladenosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA threonylcarbamoyladenosine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance via recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of EKC/KEOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EKC/KEOPS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chromatin DNA-binding EKC/KEOPS complex subunit PCC1
    NP_878113.4
    • Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; other complex members are Kae1p, Gon7p, Bud32p, and Cgi121p; ortholog of human LAGE3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      625864..626205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184522.3 → NP_878113.4  TPA: chromatin DNA-binding EKC/KEOPS complex subunit PCC1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_878113.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXF6, Q3E833
      UniProtKB/TrEMBL
      A7A055, B3LRH0, C8ZCQ5, G2WIC3, N1NZL1
      Conserved Domains (1) summary
      pfam09341
      Location:12 → 85
      Pcc1; Transcription factor Pcc1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E833.1

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