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    YOS1 Yos1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856806, updated on 9-Dec-2024

    Summary

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    Official Symbol
    YOS1
    Official Full Name
    Yos1p
    Primary source
    SGD:S000007651
    Locus tag
    YER074W-A
    See related
    AllianceGenome:SGD:S000007651; FungiDB:YER074W-A; VEuPathDB:YER074W-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum membrane. Orthologous to human IER3IP1 (immediate early response 3 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See YOS1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_001137.3 (307653..308123)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase (NAD(P)(+)) ALD5 Neighboring gene ribosomal 40S subunit protein S24A Neighboring gene tyrosine protein phosphatase PTP3 Neighboring gene tRNA-Ala

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yos1p is a novel subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex. Heidtman M, et al. Mol Biol Cell, 2005 Apr. PMID 15659647, Free PMC Article
    2. Multicopy suppressor analysis of thermosensitive YIP1 alleles implicates GOT1 in transport from the ER. Lorente-Rodríguez A, et al. J Cell Sci, 2009 May 15. PMID 19383723, Free PMC Article
    3. Genomic exploration of the hemiascomycetous yeasts: 4. The genome of Saccharomyces cerevisiae revisited. Blandin G, et al. FEBS Lett, 2000 Dec 22. PMID 11152879
    4. ATP synthase interactome analysis identifies a new subunit l as a modulator of permeability transition pore in yeast. Panja C, et al. Sci Rep, 2023 Mar 7. PMID 36882574, Free PMC Article
    5. Endosome and Golgi-associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism. Schmidt O, et al. EMBO J, 2019 Aug 1. PMID 31368600, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yos1p associates with Yip1p and Yif1p, indicating Yos1p is a novel subunit of the Yip1p-Yif1p complex
      Title: Yos1p is a novel subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in COPII-coated ER to Golgi transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in COPII-coated ER to Golgi transport vesicle IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Yos1p
    NP_219496.2
    • Integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      307653..308123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184512.1 → NP_219496.2  TPA: Yos1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_219496.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLY0, Q3E834
      UniProtKB/TrEMBL
      A6ZR29, B3LRJ1, C7GRQ6, C8Z783, G2WCW4
      Conserved Domains (1) summary
      pfam08571
      Location:6 → 85
      Yos1; Yos1-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E834.1

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