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    cdc13 G2/M B-type cyclin Cdc13 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540880, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cdc13
    Official Full Name
    G2/M B-type cyclin Cdc13
    Primary source
    PomBase:SPBC582.03
    Locus tag
    SPOM_SPBC582.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See cdc13 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (420111..423276)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein Ppr10 Neighboring gene ncRNA Neighboring gene exocyst complex subunit Exo70 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein dsh1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and sequencing of the cyclin-related cdc13+ gene and a cytological study of its role in fission yeast mitosis. Hagan I, et al. J Cell Sci, 1988 Dec. PMID 2908246
    2. Cyclin B (p56cdc13) localization in the yeast Schizosaccharomyces pombe: an ultrastructural and immunocytochemical study. Audit M, et al. Biol Cell, 1996. PMID 8688826
    3. Analysis of the role of phosphorylation in fission yeast Cdc13p/cyclinB function. Ren L, et al. J Biol Chem, 2005 Apr 15. PMID 15705571
    4. The fission yeast S-phase cyclin Cig2 can drive mitosis. Pickering M, et al. Genetics, 2021 Mar 3. PMID 33683349, Free PMC Article
    5. A dominant negative allele of p34cdc2 shows altered phosphoamino acid content and sequesters p56cdc13 cyclin. Fleig UN, et al. Mol Cell Biol, 1992 May. PMID 1533272, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study presents evidence in favour of selective inhibition of Atf1's ability to activate cdc13+ transcription; show that Pcr1 can specifically inhibit the recruitment of Atf1 on cdc13 promoter thereby preventing Atf1-mediated mitotic acceleration; also show that this opposition of Atf1 functions by Pcr1 extends to the G1-S transition event
      Title: Antagonistic regulation of cyclin expression by the bZIP transcription factors Pcr1 and Atf1 during G2/M transition.
    2. Data suggest that Cdc2 is a likely client for the Cdc37 molecular chaperone, and that inactivation of Cdc2 appears to result from the inability to form complexes with its mitotic cyclin partner Cdc13.
      Title: Activity of Cdc2 and its interaction with the cyclin Cdc13 depend on the molecular chaperone Cdc37 in Schizosaccharomyces pombe.
    3. Cdc13p accumulates in the nucleolus in response to G(2) checkpoint delays, rather than in the cytoplasm, and that phosphorylation plays no role in Cdc13p localization or function
      Title: Analysis of the role of phosphorylation in fission yeast Cdc13p/cyclinB function.
    4. Mes1p is a factor that suppresses the degradation of cyclin Cdc13p at anaphase I
      Title: Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p.
    5. regulation of Cdc13p and Cdc2p is required for G2 arrest in splicing mutants of S. pombe
      Title: Regulation of Cdc2p and Cdc13p is required for cell cycle arrest induced by defective RNA splicing in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase activator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic DNA damage checkpoint signaling EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in negative regulation of ascospore formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic sister chromatid biorientation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in positive regulation of mitotic sister chromatid biorientation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in traversing start control point of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, telomeric repeat region EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in mitotic spindle HDA PubMed 
    is_active_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle midzone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body HDA PubMed 
    is_active_in mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in new mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear periphery EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolar peripheral inclusion body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in old mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G2/M B-type cyclin Cdc13

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      420111..423276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001355823.2 → NP_001342891.1  G2/M B-type cyclin Cdc13 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P10815, Q9UU16
      Conserved Domains (1) summary
      COG5024
      Location:5 → 454
      COG5024; Cyclin [Cell division and chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version

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