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    htb1 histone H2B Htb1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539523, updated on 18-Sep-2024

    Summary

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    Official Symbol
    htb1
    Official Full Name
    histone H2B Htb1
    Primary source
    PomBase:SPCC622.09
    Locus tag
    SPOM_SPCC622.09
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See htb1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1412359..1413677)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene histone H2A alpha Neighboring gene exocyst complex subunit Sec5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene plasma membrane LMBR1-like multi-pass membrane protein, human LMBRD2 ortholog, implicated in signaling

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of Uhp1, a ubiquitinated histone-like protein, as a target/mediator of Rhp6 in mating-type silencing in fission yeast. Naresh A, et al. J Biol Chem, 2003 Mar 14. PMID 12511578
    2. Histone H2B ubiquitylation represses gametogenesis by opposing RSC-dependent chromatin remodeling at the ste11 master regulator locus. Materne P, et al. Elife, 2016 May 12. PMID 27171419, Free PMC Article
    3. In vitro reconstitution and biochemical analyses of the Schizosaccharomyces pombe nucleosome. Koyama M, et al. Biochem Biophys Res Commun, 2017 Jan 22. PMID 27890612
    4. HULC, a histone H2B ubiquitinating complex, modulates heterochromatin independent of histone methylation in fission yeast. Zofall M, et al. J Biol Chem, 2007 May 11. PMID 17363370
    5. Regulation of Set9-mediated H4K20 methylation by a PWWP domain protein. Wang Y, et al. Mol Cell, 2009 Feb 27. PMID 19250904, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Therefore, ubiquitylated histone H2B represses gametogenesis by opposing the recruitment of RSC complex proteins at the promoter of the master regulator ste11 gene.
      Title: Histone H2B ubiquitylation represses gametogenesis by opposing RSC-dependent chromatin remodeling at the ste11 master regulator locus.
    2. CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent DNA repair resection.
      Title: CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection.
    3. Transcription elongation in fission yeast is regulated by opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation.
      Title: A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin-protein adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling NAS
    Non-traceable Author Statement
    more info
    		  
    involved_in double-strand break repair via homologous recombination EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nucleosome ISM
    Inferred from Sequence Model
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone H2B Htb1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1412359..1413677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023171.3 → NP_588181.1  histone H2B Htb1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588181.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P04913
      Conserved Domains (1) summary
      smart00427
      Location:27 → 123
      H2B; Histone H2B
    Nucleotide Protein
    Heading Accession and Version

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