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    par1 serine/threonine protein phosphatase PP2A regulatory subunit B-56 Par1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539379, updated on 14-Nov-2024

    Summary

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    Official Symbol
    par1
    Official Full Name
    serine/threonine protein phosphatase PP2A regulatory subunit B-56 Par1
    Primary source
    PomBase:SPCC188.02
    Locus tag
    SPOM_SPCC188.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    pbp1
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    Genomic context

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    See par1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003421.2 (1475573..1478103)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene 5S ribosomal RNA Neighboring gene ncRNA Neighboring gene tRNA-Lys Neighboring gene Ndc80 complex subunit Spc25 Neighboring gene condensin complex non-SMC subunit Cnd3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Requirement of PP2A-B56(Par1) for the Stabilization of the CDK Inhibitor Rum1 and Activation of APC/C(Ste9) during Pre-Start G1 in S. pombe. Stonyte V, et al. iScience, 2020 May 22. PMID 32361273, Free PMC Article
    2. Isolation and characterization of par1(+) and par2(+): two Schizosaccharomyces pombe genes encoding B' subunits of protein phosphatase 2A. Jiang W, et al. Genetics, 2000 Mar. PMID 10757751, Free PMC Article
    3. Analysis of the potential role of fission yeast PP2A in spindle assembly checkpoint inactivation. Deng DJ, et al. FASEB J, 2022 Sep. PMID 36006032
    4. Fission yeast homologues of the B' subunit of protein phosphatase 2A: multiple roles in mitotic cell division and functional interaction with calcineurin. Tanabe O, et al. Genes Cells, 2001 May. PMID 11380623
    5. Correct regulation of the septation initiation network in Schizosaccharomyces pombe requires the activities of par1 and par2. Jiang W, et al. Genetics, 2001 Aug. PMID 11514436, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase activator activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-macromolecule adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in deactivation of mitotic spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic centromeric cohesion protection in anaphase I EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in meiotic centromeric cohesion protection in anaphase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic G1 cell size control checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of septation initiation signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of septation initiation signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in traversing start control point of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site HDA PubMed 
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    part_of inner kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body HDA PubMed 
    is_active_in mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein phosphatase type 2A complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine protein phosphatase PP2A regulatory subunit B-56 Par1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1475573..1478103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023196.3 → NP_588206.1  serine/threonine protein phosphatase PP2A regulatory subunit B-56 Par1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588206.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10428
      Conserved Domains (2) summary
      PLN00122
      Location:421 → 522
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:114 → 516
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)
    Nucleotide Protein
    Heading Accession and Version

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