BIK1 Bik1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: BIK1
Official Full Name: Bik1p
Primary source: SGD:S000000534
Locus tag: YCL029C
See related: AllianceGenome:SGD:S000000534; FungiDB:YCL029C; VEuPathDB:YCL029C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ARM5; PAC14
Summary: Enables kinesin binding activity and microtubule binding activity. Involved in several processes, including 2-micrometer plasmid partitioning; karyogamy involved in conjugation with cellular fusion; and nuclear migration involved in conjugation with cellular fusion. Acts upstream of or within microtubule nucleation and protein localization to mitotic spindle pole body. Located in cell cortex; mating projection tip; and microtubule cytoskeleton. Is active in kinetochore. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See BIK1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_001135.5 (68599..69921, complement)

Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The motor domain of the kinesin Kip2 promotes microtubule polymerization at microtubule tips.
Title: The motor domain of the kinesin Kip2 promotes microtubule polymerization at microtubule tips.
Multivalency ensures persistence of a +TIP body at specialized microtubule ends.
Title: Multivalency ensures persistence of a +TIP body at specialized microtubule ends.
The microtubule plus-end tracking protein Bik1 is required for chromosome congression.
Title: The microtubule plus-end tracking protein Bik1 is required for chromosome congression.
Structure-function relationship of the Bik1-Bim1 complex has been reported.
Title: Structure-Function Relationship of the Bik1-Bim1 Complex.
the microtubule-associated proteins Bik1 and Bim1 are important host factors in the process of plasmid localization to a certain sub-nuclear locale probably assisted by the motor protein, Kip1 and microtubules, perhaps by acting as an adapter between the plasmid and the motor and thus helping to anchor the plasmid to microtubules.
Title: Microtubule-associated proteins, Bik1 and Bim1, are required for faithful partitioning of the endogenous 2 micron plasmids in budding yeast.
These results indicate that Bik1p interactions with tubulin are important for Bik1p plus-end tracking, and suggest alternative pathways for Bik1p-Kip2p-dependent dynein localization at plus ends.
Title: A new role for kinesin-directed transport of Bik1p (CLIP-170) in Saccharomyces cerevisiae.
functions of Bik1p and the various roles that Bik1p plays in positioning the mitotic spindle
Title: The CLIP-170 orthologue Bik1p and positioning the mitotic spindle in yeast.
Bik1p has a previously uncharacterized function in the separation of duplicated Spindle Pole Bodies.
Title: Deletion of RNQ1 gene reveals novel functional relationship between divergently transcribed Bik1p/CLIP-170 and Sfi1p in spindle pole body separation.
Bik1p promotes the phosphorylation of Kar9p on serine 496, which affects its asymmetric localization to one SPB and associated cytoplasmic microtubules
Title: The CLIP-170 homologue Bik1p promotes the phosphorylation and asymmetric localization of Kar9p.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables kinesin binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 2-micrometer plasmid partitioning	IGI Inferred from Genetic Interaction more info	PubMed
involved_in 2-micrometer plasmid partitioning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in karyogamy involved in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule nucleation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle elongation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of microtubule polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear migration involved in conjugation with cellular fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear migration involved in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to mitotic spindle pole body	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell tip	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
part_of microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule plus-end	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in spindle microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle pole body	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole body	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole body	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Bik1p

NP_009901.1

Microtubule-associated protein; component of the interface between microtubules and the kinetochore; involved in sister chromatid separation and mitotic spindle elongation; involved in karyogamy during mating; stabilizes Kip2p at microtubule plus ends and recruits Kip2p to mitotic SPBs; essential in polyploid cells but not in haploid or diploid cells; promotes plus-end directed movement of Dyn1p; ortholog of mammalian CLIP-170

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001135.5 Reference assembly

Range

68599..69921 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178674.1 → NP_009901.1 TPA: Bik1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009901.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQY6, P11709

UniProtKB/TrEMBL

A6ZTG1, B3LU53, C7GSY6, C8Z459, G2W9Z6, N1P988

Conserved Domains (2) summary

TIGR02168
Location:193 → 395

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam01302
Location:8 → 73

CAP_GLY; CAP-Gly domain