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    spi1 Ran GTPase Spi1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540149, updated on 18-Sep-2024

    Summary

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    Official Symbol
    spi1
    Official Full Name
    Ran GTPase Spi1
    Primary source
    PomBase:SPBC1289.03c
    Locus tag
    SPOM_SPBC1289.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See spi1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (4386149..4387361, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SEL1/TPR repeat protein1, 3-beta-glucan synthase regulatory factor Chf3/Chr4 Neighboring gene ncRNA Neighboring gene U2 snRNP-associated protein Uap2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Boi family protein Neighboring gene ncRNA Neighboring gene V-type ATPase V1 domain subunit G

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spi1 GTPase interacts with RCC1 to maintain interdependency of cell cycle events. Matsumoto T, et al. Princess Takamatsu Symp, 1991. PMID 1844237
    2. Isolation and characterization of fission yeast sns mutants defective at the mitosis-to-interphase transition. Matynia A, et al. Genetics, 1998 Apr. PMID 9560394, Free PMC Article
    3. Schizosaccharomyces pombe Snf2SR, a novel SNF2 family protein, interacts with Ran GTPase and modulates both RanGEF and RanGAP activities. Ohba T, et al. Genes Cells, 2008 Jun. PMID 18422602
    4. A fission yeast RCC1-related protein is required for the mitosis to interphase transition. Sazer S, et al. EMBO J, 1994 Feb 1. PMID 8313905, Free PMC Article
    5. Loss of RanGEF/Pim1 activity abolishes the orchestration of Ran-mediated mitotic cellular events in S. pombe. Hirose E, et al. Genes Cells, 2006 Jan. PMID 16371130

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Snf2SR directly bound to the GDP-bound form of the S. pombe Ran homologue Spi1 and enhanced the nucleotide exchange activity of Pim1, the S. pombe RanGEF (guanine nucleotide exchange factor).
      Title: Schizosaccharomyces pombe Snf2SR, a novel SNF2 family protein, interacts with Ran GTPase and modulates both RanGEF and RanGAP activities.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GTP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in poly(A)+ mRNA export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ran GTPase Spi1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      4386149..4387361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023848.3 → NP_596827.1  Ran GTPase Spi1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596827.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P28748
      Conserved Domains (2) summary
      cd00877
      Location:10 → 175
      Ran; Ras-related nuclear proteins (Ran)/TC4 family of small GTPases
      PTZ00132
      Location:1 → 213
      PTZ00132; GTP-binding nuclear protein Ran; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAB25844.1

    Gene LinkOut

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