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    PLS1 Pls1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 1466513, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PLS1
    Official Full Name
    Pls1p
    Primary source
    SGD:S000028699
    Locus tag
    YNL097C-B
    See related
    AllianceGenome:SGD:S000028699; FungiDB:YNL097C-B; VEuPathDB:YNL097C-B
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YNL097C-A
    Summary
    Acts upstream of or within regulation of lysine biosynthetic process via aminoadipic acid. Located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PLS1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (440797..440919, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative tyrosine protein phosphatase OCA1 Neighboring gene Ras family GTPase RAS2 Neighboring gene Pho23p Neighboring gene tRNA-Leu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pls1 Is a Peroxisomal Matrix Protein with a Role in Regulating Lysine Biosynthesis. David Y, et al. Cells, 2022 Apr 22. PMID 35563734, Free PMC Article
    2. The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications. Philippsen P, et al. Nature, 1997 May 29. PMID 9169873
    3. Global analysis of yeast mRNPs. Mitchell SF, et al. Nat Struct Mol Biol, 2013 Jan. PMID 23222640, Free PMC Article
    4. A systematic proximity ligation approach to studying protein-substrate specificity identifies the substrate spectrum of the Ssh1 translocon. Cohen N, et al. EMBO J, 2023 Jun 1. PMID 37073826, Free PMC Article
    5. A global genetic interaction network maps a wiring diagram of cellular function. Costanzo M, et al. Science, 2016 Sep 23. PMID 27708008, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of lysine biosynthetic process via aminoadipic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pls1p
    NP_878155.1
    • Peroxisomal matrix protein that regulates lysine biosynthesis; localization to peroxisomes upon lysine deprivation is dependent on targeting factor Pex5p and lysine biosynthesis enzyme Lys1p; affects abundance of Lys1p and the lysine biosynthesis pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      440797..440919 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184620.1 → NP_878155.1  TPA: Pls1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_878155.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W182, P0C271, Q8TGS3
      UniProtKB/TrEMBL
      A6ZRY3, B3LNV6, C7GR81, C8ZGD2, G2WM07
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C271.1

    Gene LinkOut

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