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    GON7 chromatin DNA-binding EKC/KEOPS complex subunit GON7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853255, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GON7
    Official Full Name
    chromatin DNA-binding EKC/KEOPS complex subunit GON7
    Primary source
    SGD:S000003720
    Locus tag
    YJL184W
    See related
    AllianceGenome:SGD:S000003720; FungiDB:YJL184W; VEuPathDB:YJL184W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LDB6; PCC2
    Summary
    Enables chromatin DNA binding activity. Involved in cell wall mannoprotein biosynthetic process; positive regulation of transcription by RNA polymerase II; and telomere maintenance via recombination. Located in chromatin. Part of EKC/KEOPS complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GON7 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (83448..83819)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene alpha-1,2-mannosyltransferase MNN5 Neighboring gene Atg36p Neighboring gene alpha-1,6-mannosyltransferase Neighboring gene Rbh1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex. Zhang W, et al. Nucleic Acids Res, 2015 Mar 31. PMID 25735745, Free PMC Article
    2. Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis. Wan LC, et al. Nucleic Acids Res, 2016 Aug 19. PMID 27302132, Free PMC Article
    3. Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. Wan LC, et al. Nucleic Acids Res, 2013 Jul. PMID 23620299, Free PMC Article
    4. Cell polarity in Saccharomyces cerevisiae depends on proper localization of the Bud9 landmark protein by the EKC/KEOPS complex. Kato Y, et al. Genetics, 2011 Aug. PMID 21625000, Free PMC Article
    5. The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. Srinivasan M, et al. EMBO J, 2011 Mar 2. PMID 21183954, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We found that Gon7 forms a stable heterodimer with Pcc1 and report the crystal structure of the Pcc1-Gon7 heterodimer.
      Title: Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex.
    2. EKC/KEOPS complex is specifically involved in the regulation of Bud9p localization downstream of Rax1p/Rax2p.
      Title: Cell polarity in Saccharomyces cerevisiae depends on proper localization of the Bud9 landmark protein by the EKC/KEOPS complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall mannoprotein biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance via recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of EKC/KEOPS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chromatin DNA-binding EKC/KEOPS complex subunit GON7
    NP_012351.1
    • Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; implicated in osmotic stress response; other complex members are Kae1p, Cgi121p, Pcc1p, and Bud32p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      83448..83819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181617.1 → NP_012351.1  TPA: chromatin DNA-binding EKC/KEOPS complex subunit GON7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012351.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW06, P46984
      UniProtKB/TrEMBL
      A6ZQF1, B3LPU2, C7GS09, C8ZB35, G2WGJ2, N1P1V7
      Conserved Domains (1) summary
      pfam08738
      Location:4 → 110
      Gon7; Gon7 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46984.1

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