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    cut1 separase/separin [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539442, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cut1
    Official Full Name
    separase/separin
    Primary source
    PomBase:SPCC5E4.04
    Locus tag
    SPOM_SPCC5E4.04
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    ptr4
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    Genomic context

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    See cut1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003421.2 (643409..649578)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene transcription initiation factor TFIID subunit 5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene serine hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cut1/separase C-terminus affects spindle pole body positioning in interphase of fission yeast: pointed nuclear formation. Nakamura T, et al. Genes Cells, 2002 Nov. PMID 12390246
    2. Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase. Vijayakumari D, et al. Cell Rep, 2022 Mar 22. PMID 35320724, Free PMC Article
    3. The fission yeast cut1+ gene regulates spindle pole body duplication and has homology to the budding yeast ESP1 gene. Uzawa S, et al. Cell, 1990 Sep 7. PMID 2203537
    4. Cut1 is loaded onto the spindle by binding to Cut2 and promotes anaphase spindle movement upon Cut2 proteolysis. Kumada K, et al. Curr Biol, 1998 May 21. PMID 9635190
    5. A screen for genes involved in the anaphase proteolytic pathway identifies tsm1(+), a novel Schizosaccharomyces pombe gene important for microtubule integrity. Grishchuk EL, et al. Genetics, 1998 Jul. PMID 9649518, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables endopeptidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic chromosome separation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic chromosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of separase-securin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    separase/separin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      643409..649578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022895.3 → NP_587903.1  separase/separin [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587903.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94304, P18296
      Conserved Domains (1) summary
      COG5155
      Location:38 → 1828
      ESP1; Separase, a protease involved in sister chromatid separation [Cell division and chromosome partitioning / Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version

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