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    rga4 Rho-type GTPase-activating protein Rga4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540593, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rga4
    Official Full Name
    Rho-type GTPase-activating protein Rga4
    Primary source
    PomBase:SPBC28E12.03
    Locus tag
    SPOM_SPBC28E12.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rga4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003423.3 (1839416..1843187)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene BICC1 family RNA-binding protein Neighboring gene anaphase-promoting complex TPR lobe accessory factor Apc13 Neighboring gene ncRNA Neighboring gene protein Cbp7 Neighboring gene U3 snoRNP-associated protein Esf2 Neighboring gene beige protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cdc42 GTPase-activating proteins (GAPs) regulate generational inheritance of cell polarity and cell shape in fission yeast. Pino MR, et al. Mol Biol Cell, 2021 Oct 1. PMID 34288736, Free PMC Article
    2. Rga4, a Rho-GAP from fission yeast: Finding specificity within promiscuity. Cansado J, et al. Commun Integr Biol, 2010 Sep. PMID 21057634, Free PMC Article
    3. Cdc42 GTPase activating proteins Rga4 and Rga6 coordinate septum synthesis and membrane trafficking at the division plane during cytokinesis. Campbell BF, et al. Traffic, 2022 Oct. PMID 36068165
    4. Regulation of cell diameter, For3p localization, and cell symmetry by fission yeast Rho-GAP Rga4p. Das M, et al. Mol Biol Cell, 2007 Jun. PMID 17377067, Free PMC Article
    5. Differential GAP requirement for Cdc42-GTP polarization during proliferation and sexual reproduction. Gallo Castro D, et al. J Cell Biol, 2018 Dec 3. PMID 30279276, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cdc42 GTPase activating proteins Rga4 and Rga6 coordinate septum synthesis and membrane trafficking at the division plane during cytokinesis.
      Title: Cdc42 GTPase activating proteins Rga4 and Rga6 coordinate septum synthesis and membrane trafficking at the division plane during cytokinesis.
    2. Cdc42 GTPase-activating proteins (GAPs) regulate generational inheritance of cell polarity and cell shape in fission yeast.
      Title: Cdc42 GTPase-activating proteins (GAPs) regulate generational inheritance of cell polarity and cell shape in fission yeast.
    3. Rga4 modulates the activity of the fission yeast cell integrity MAPK pathway by acting as a Rho2 GTPase-activating protein
      Title: Rga4 modulates the activity of the fission yeast cell integrity MAPK pathway by acting as a Rho2 GTPase-activating protein.
    4. Results indicate that Rga4p functionally interacts with For3p and has a novel function in the control of cell diameter and cell growth.
      Title: Regulation of cell diameter, For3p localization, and cell symmetry by fission yeast Rho-GAP Rga4p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables GTPase activator activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment or maintenance of bipolar cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cell integrity MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of establishment of bipolar cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of establishment of cell polarity regulating cell shape EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell wall organization or biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lateral cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lateral plasma membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in medial cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in site of polarized growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rho-type GTPase-activating protein Rga4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1839416..1843187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021656.3 → NP_595756.1  Rho-type GTPase-activating protein Rga4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595756.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74360
      Conserved Domains (2) summary
      smart00324
      Location:759 → 928
      RhoGAP; GTPase-activator protein for Rho-like GTPases
      cd08368
      Location:24 → 78
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    Nucleotide Protein
    Heading Accession and Version

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