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    hrq1 RecQ type DNA helicase Hrq1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542036, updated on 14-Nov-2024

    Summary

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    Official Symbol
    hrq1
    Official Full Name
    RecQ type DNA helicase Hrq1
    Primary source
    PomBase:SPAC23A1.19c
    Locus tag
    SPOM_SPAC23A1.19C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPAC26H5.01c
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    Genomic context

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    See hrq1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (4113673..4117214, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mitochondrial 37S ribosomal protein bS1m Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA replication ATPase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks. Ganguly A, et al. PLoS Genet, 2018 Aug. PMID 30148840, Free PMC Article
    2. The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast. Groocock LM, et al. Mol Cell Biol, 2012 Jan. PMID 22064477, Free PMC Article
    3. Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth. Rallis C, et al. Biol Open, 2014 Feb 15. PMID 24463365, Free PMC Article
    4. Large scale screening of genetic interaction with sgf73(+) in fission yeast. Guo Y, et al. Yi Chuan, 2014 Jul. PMID 25076038
    5. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Roguev A, et al. Science, 2008 Oct 17. PMID 18818364, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cells lacking Hrq1 suffer spontaneous genomic instability and, consequently, require homologous recombination repair and the DNA damage checkpoint for viability.
      Title: The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables bubble DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in UV-damage excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in nucleotide-excision repair involved in interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RecQ type DNA helicase Hrq1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4113673..4117214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019877.3 → NP_594448.2  RecQ type DNA helicase Hrq1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594448.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13983, O42856
      Conserved Domains (5) summary
      smart01075
      Location:51 → 222
      CDT1; DNA replication factor CDT1 like
      COG1205
      Location:257 → 1063
      YprA; ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair]
      pfam00270
      Location:313 → 490
      DEAD; DEAD/DEAH box helicase
      pfam00271
      Location:531 → 653
      Helicase_C; Helicase conserved C-terminal domain
      pfam09369
      Location:915 → 1007
      DUF1998; Domain of unknown function (DUF1998)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials