scd1 RhoGEF Scd1 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: scd1
Official Full Name: RhoGEF Scd1
Primary source: PomBase:SPAC16E8.09
Locus tag: SPOM_SPAC16E8.09
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: ral1
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Genomic context

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See scd1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 2

Sequence:: Chromosome: I; NC_003424.3 (3515547..3518734)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fission yeast cell polarity was regulated by coordination of 'local' (Scd1) and 'global' (Gef1) Cdc42 GEFs via microtubules and Tea1-Tea4-Pom1 axis.
Title: Local and global Cdc42 guanine nucleotide exchange factors for fission yeast cell polarity are coordinated by microtubules and the Tea1-Tea4-Pom1 axis.
Unique role of Scd1 in the regulation of distinct events during cytokinesis:Scd1 localizes to the ingressing membrane and promotes septum formation.
Title: Unique spatiotemporal activation pattern of Cdc42 by Gef1 and Scd1 promotes different events during cytokinesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	EXP Inferred from Experiment more info	PubMed
enables lipid binding	ISM Inferred from Sequence Model more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of bipolar cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of bipolar cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mating projection assembly	EXP Inferred from Experiment more info	PubMed
involved_in positive regulation of mating projection assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic division septum assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of division septum assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septin ring organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Cdc42 GTPase complex	TAS Traceable Author Statement more info	PubMed
is_active_in cell cortex of cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell cortex of growing cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell division site	HDA more info	PubMed
is_active_in cell division site	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
is_active_in cortical dynamic polarity patch	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	HDA more info	PubMed
is_active_in division septum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in division septum	IDA Inferred from Direct Assay more info	PubMed
is_active_in mating projection tip	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane of cell tip	EXP Inferred from Experiment more info	PubMed
is_active_in site of polarized growth	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RhoGEF Scd1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003424.3 Reference assembly

Range

3515547..3518734

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001019644.3 → NP_594221.1 RhoGEF Scd1 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_594221.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P40995

Conserved Domains (4) summary

smart00666
Location:775 → 848

PB1; PB1 domain

cd13246
Location:404 → 546

PH_Scd1; Shape and Conjugation Deficiency 1 Pleckstrin homology (PH) domain

pfam00621
Location:232 → 401

RhoGEF; RhoGEF domain

pfam06395
Location:105 → 194

CDC24; CDC24 Calponin