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    ctf18 Ctf18 RFC-like complex subunit Ctf18 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541270, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ctf18
    Official Full Name
    Ctf18 RFC-like complex subunit Ctf18
    Primary source
    PomBase:SPBC902.02c
    Locus tag
    SPOM_SPBC902.02C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    chl12
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    Genomic context

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    See ctf18 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (483878..486967, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene U3 snoRNP protein Utp15 Neighboring gene gamma tubulin complex GCP3 subunit Alp6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein phosphatase regulator Nem2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Checkpoint-dependent and -independent roles of Swi3 in replication fork recovery and sister chromatid cohesion in fission yeast. Rapp JB, et al. PLoS One, 2010 Oct 12. PMID 20967229, Free PMC Article
    2. Kinetochore geometry defined by cohesion within the centromere. Sakuno T, et al. Nature, 2009 Apr 16. PMID 19370027
    3. Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenance. Khair L, et al. Cell Cycle, 2010 Jun 1. PMID 20505337, Free PMC Article
    4. Contrasting effects of Elg1-RFC and Ctf18-RFC inactivation in the absence of fully functional RFC in fission yeast. Kim J, et al. Nucleic Acids Res, 2005. PMID 16040599, Free PMC Article
    5. New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion. Gellon L, et al. PLoS Genet, 2011 Feb 10. PMID 21347277, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Together these results indicate that Ctf18-RFC has additional important functions in preserving genome stability, besides its role in sister chromatid cohesion, which we propose include lesion bypass by replication forks and post-replication repair.
      Title: New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.
    2. RFC(Ctf18) and the Swi1-Swi3 complex function in separate and redundant pathways essential for replication fork stabilization to facilitate sister chromatid cohesion in fission yeast.
      Title: RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity NAS
    Non-traceable Author Statement
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to DNA clamp loader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated DNA replication maintenance of fidelity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication maintenance of fidelity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nuclear replication fork IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ctf18 RFC-like complex subunit Ctf18

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      483878..486967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021106.3 → NP_595200.1  Ctf18 RFC-like complex subunit Ctf18 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595200.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9USQ1, Q9UTY7
      Conserved Domains (3) summary
      cd00009
      Location:412 → 553
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00382
      Location:416 → 554
      AAA; ATPases associated with a variety of cellular activities
      COG0470
      Location:482 → 647
      HolB; DNA polymerase III, delta prime subunit [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version

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