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    MGR1 Mgr1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850313, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MGR1
    Official Full Name
    Mgr1p
    Primary source
    SGD:S000000549
    Locus tag
    YCL044C
    See related
    AllianceGenome:SGD:S000000549; FungiDB:YCL044C; VEuPathDB:YCL044C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables misfolded protein binding activity. Involved in protein quality control for misfolded or incompletely synthesized proteins. Located in mitochondrion. Part of i-AAA complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MGR1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (47111..48364, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene nicotinamide-nucleotide adenylyltransferase Neighboring gene Emc1p Neighboring gene protein disulfide isomerase PDI1 Neighboring gene uncharacterized protein Neighboring gene glucokinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial inner-membrane protease Yme1 degrades outer-membrane proteins Tom22 and Om45. Wu X, et al. J Cell Biol, 2018 Jan 2. PMID 29138251, Free PMC Article
    2. Metabolic and environmental conditions determine nuclear genomic instability in budding yeast lacking mitochondrial DNA. Dirick L, et al. G3 (Bethesda), 2014 Mar 20. PMID 24374640, Free PMC Article
    3. Defects associated with mitochondrial DNA damage can be mitigated by increased vacuolar pH in Saccharomyces cerevisiae. Garipler G, et al. Genetics, 2013 May. PMID 23502676, Free PMC Article
    4. A genomewide screen for petite-negative yeast strains yields a new subunit of the i-AAA protease complex. Dunn CD, et al. Mol Biol Cell, 2006 Jan. PMID 16267274, Free PMC Article
    5. Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complex. Dunn CD, et al. Mol Biol Cell, 2008 Dec. PMID 18843051, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables misfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein quality control for misfolded or incompletely synthesized proteins IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of i-AAA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mgr1p
    NP_009886.1
    • Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      47111..48364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178689.1 → NP_009886.1  TPA: Mgr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009886.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZTE8, D6VQX2, P25573
      UniProtKB/TrEMBL
      B3LU40, B5VER7, C7GSZ9, C8Z446, N1P982
      Conserved Domains (1) summary
      pfam08602
      Location:1 → 388
      Mgr1; Mgr1-like, i-AAA protease complex subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25573.1

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