GSTA5 glutathione S-transferase alpha 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GSTA5provided by HGNC
Official Full Name: glutathione S-transferase alpha 5provided by HGNC
Primary source: HGNC:HGNC:19662
See related: Ensembl:ENSG00000182793 MIM:607605; AllianceGenome:HGNC:19662
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The glutathione S-transferases (GST; EC 2.5.1.18) catalyze the conjugation of reduced glutathiones and a variety of electrophiles, including many known carcinogens and mutagens. The cytosolic GSTs belong to a large superfamily, with members located on different chromosomes. For additional information on GSTs, see GSTA1 (MIM 138359).[supplied by OMIM, Sep 2008]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 6p12.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (52831692..52846245, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (52671168..52685725, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (52696646..52705611, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We observed suggestive associations between survival and GSTT1 copy number and GSTA5, GSTM4, and ABCC4 single nucleotide polymorphisms
Title: Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.
Data show that hGSTA5 can be processed to a mature mRNA which is translation-competent, producing a catalytically active enzyme.
Title: The human hGSTA5 gene encodes an enzymatically active protein.
Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:481626

RH71356 (e-PCR)
- UniSTS:76642

NoName (e-PCR)
- UniSTS:490348

NoName (e-PCR)
- UniSTS:482182

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in extracellular exosome	HDA more info	PubMed

General protein information

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Preferred Names: glutathione S-transferase A5

Names: GST class-alpha member 5; glutathione S-transferase A5-5

NP_714543.1

EC 2.5.1.18

XP_054184397.1

EC 2.5.1.18

XP_054210529.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153699.3 → NP_714543.1 glutathione S-transferase A5

See identical proteins and their annotated locations for NP_714543.1

Status: VALIDATED

Source sequence(s)

AL590363

Consensus CDS

CCDS4946.1

UniProtKB/Swiss-Prot

Q5SZC2, Q7RTV2

Related

ENSP00000360028.1, ENST00000370989.7

Conserved Domains (3) summary

PTZ00057
Location:1 → 198

PTZ00057; glutathione s-transferase; Provisional

cd03208
Location:86 → 220

GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases

cd03077
Location:4 → 82

GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...