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    IFI6 interferon alpha inducible protein 6 [ Homo sapiens (human) ]

    Gene ID: 2537, updated on 10-Dec-2024

    Summary

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    Official Symbol
    IFI6provided by HGNC
    Official Full Name
    interferon alpha inducible protein 6provided by HGNC
    Primary source
    HGNC:HGNC:4054
    See related
    Ensembl:ENSG00000126709 MIM:147572; AllianceGenome:HGNC:4054
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    6-16; G1P3; FAM14C; IFI616; IFI-6-16
    Summary
    This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in placenta (RPKM 111.6), salivary gland (RPKM 40.6) and 21 other tissues See more
    Orthologs
    all
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    Genomic context

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    See IFI6 in Genome Data Viewer
    Location:
    1p35.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (27666064..27672192, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (27507374..27513475, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27992575..27998703, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC729973 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:27977663-27978629 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:27981022-27981424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27985747-27986247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 527 Neighboring gene long intergenic non-protein coding RNA 2574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27988849-27989364 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27989365-27989880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 568 Neighboring gene RNA, U6 small nuclear 949, pseudogene Neighboring gene Sharpr-MPRA regulatory region 2074 Neighboring gene charged multivesicular body protein 1A pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of interferon alpha-inducible protein 6 in modulating the proliferation, apoptosis and senescence of oesophageal squamous cell carcinoma cells. Gao Y, et al. J Physiol Pharmacol, 2023 Jun. PMID 37661181
    2. Targeted breakage of a human chromosome mediated by cloned human telomeric DNA. Itzhaki JE, et al. Nat Genet, 1992 Dec. PMID 1303280
    3. Targeted disruption of a human interferon-inducible gene detected by secretion of human growth hormone. Itzhaki JE, et al. Nucleic Acids Res, 1991 Jul 25. PMID 1713665, Free PMC Article
    4. Characterization of a human gene inducible by alpha- and beta-interferons and its expression in mouse cells. Kelly JM, et al. EMBO J, 1986 Jul. PMID 3017706, Free PMC Article
    5. Interferon response element of the human gene 6-16. Porter AC, et al. EMBO J, 1988 Jan. PMID 3359997, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of glucose-dependent insulinotropic polypeptide 3 (G1P-3) and nucleolar phosphoprotein-1 (NPM1) in pathogenesis of psoriasis.
      Title: The role of glucose-dependent insulinotropic polypeptide 3 (G1P-3) and nucleolar phosphoprotein-1 (NPM1) in pathogenesis of psoriasis.
    2. BM-MSCs display altered gene expression profiles in B-cell acute lymphoblastic leukemia niches and exert pro-proliferative effects via overexpression of IFI6.
      Title: BM-MSCs display altered gene expression profiles in B-cell acute lymphoblastic leukemia niches and exert pro-proliferative effects via overexpression of IFI6.
    3. Role of interferon alpha-inducible protein 6 in modulating the proliferation, apoptosis and senescence of oesophageal squamous cell carcinoma cells.
      Title: Role of interferon alpha-inducible protein 6 in modulating the proliferation, apoptosis and senescence of oesophageal squamous cell carcinoma cells.
    4. Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation.
      Title: Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation.
    5. IDO1, FAT10, IFI6, and GILT Are Involved in the Antiretroviral Activity of gamma-Interferon and IDO1 Restricts Retrovirus Infection by Autophagy Enhancement.
      Title: IDO1, FAT10, IFI6, and GILT Are Involved in the Antiretroviral Activity of γ-Interferon and IDO1 Restricts Retrovirus Infection by Autophagy Enhancement.
    6. The Functional and Antiviral Activity of Interferon Alpha-Inducible IFI6 Against Hepatitis B Virus Replication and Gene Expression.
      Title: The Functional and Antiviral Activity of Interferon Alpha-Inducible IFI6 Against Hepatitis B Virus Replication and Gene Expression.
    7. Interferon-alpha inducible protein 6 (IFI6) confers protection against ionizing radiation in skin cells.
      Title: Interferon-α inducible protein 6 (IFI6) confers protection against ionizing radiation in skin cells.
    8. ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells.
      Title: ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells.
    9. IFI6 depletion inhibits esophageal squamous cell carcinoma progression through reactive oxygen species accumulation via mitochondrial dysfunction and endoplasmic reticulum stress.
      Title: IFI6 depletion inhibits esophageal squamous cell carcinoma progression through reactive oxygen species accumulation via mitochondrial dysfunction and endoplasmic reticulum stress.
    10. G1P3-induced mtROS have a direct role in migratory structure formation and nuclear gene expression to promote breast cancer cell metastasis. Therefore, interrupting mitochondrial functions of G1P3 may improve clinical outcomes in breast cancer patients
      Title: G1P3 (IFI6), a mitochondrial localised antiapoptotic protein, promotes metastatic potential of breast cancer cells through mtROS.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 LAI infection downregulates UBD (FAT10) and IFI6 mRNA levels in HeLa cells, which results from IFNG signaling inhibition PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of interferon alpha-inducible protein 6 (IFI6) in human B cells PubMed
    Vpr vpr HIV-1 Vpr upregulates the gene expression of IFI6 in human monocyte-derived dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitochondrial depolarization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in release of cytochrome c from mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    interferon alpha-inducible protein 6
    Names
    interferon, alpha-inducible protein clone IFI-6-16
    interferon-induced protein 6-16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002038.4 → NP_002029.3  interferon alpha-inducible protein 6 isoform a precursor

      See identical proteins and their annotated locations for NP_002029.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shortest isoform (a).
      Source sequence(s)
      AK024814, AL445490
      Consensus CDS
      CCDS306.1
      UniProtKB/Swiss-Prot
      P09912, Q13141, Q13142, Q5VVR2, Q5VVR3, Q6IE95, Q969M8
      UniProtKB/TrEMBL
      A0A348GSI1
      Related
      ENSP00000354736.6, ENST00000361157.11
      Conserved Domains (1) summary
      pfam06140
      Location:46 → 118
      Ifi-6-16; Interferon-induced 6-16 family

    2. NM_022872.3 → NP_075010.1  interferon alpha-inducible protein 6 isoform b precursor

      See identical proteins and their annotated locations for NP_075010.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alterative, in-frame splice site compared to variant 1. The encoded isoform (b) is longer than isoform a.
      Source sequence(s)
      AK024814, AL445490
      Consensus CDS
      CCDS307.1
      UniProtKB/Swiss-Prot
      P09912
      Related
      ENSP00000355152.4, ENST00000362020.4
      Conserved Domains (1) summary
      pfam06140
      Location:50 → 111
      Ifi-6-16; Interferon-induced 6-16 family

    3. NM_022873.3 → NP_075011.1  interferon alpha-inducible protein 6 isoform c precursor

      See identical proteins and their annotated locations for NP_075011.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alterative, in-frame splice site compared to variant 1. The encoded isoform (c) is longer than isoform a.
      Source sequence(s)
      AK024814, AL445490
      Consensus CDS
      CCDS308.1
      UniProtKB/Swiss-Prot
      P09912
      Related
      ENSP00000342513.4, ENST00000339145.8
      Conserved Domains (1) summary
      pfam06140
      Location:54 → 115
      Ifi-6-16; Interferon-induced 6-16 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      27666064..27672192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      27507374..27513475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09912.2 GenPept UniProtKB/Swiss-Prot:P09912

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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