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    C1orf21 chromosome 1 open reading frame 21 [ Homo sapiens (human) ]

    Gene ID: 81563, updated on 10-Dec-2024

    Summary

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    Official Symbol
    C1orf21provided by HGNC
    Official Full Name
    chromosome 1 open reading frame 21provided by HGNC
    Primary source
    HGNC:HGNC:15494
    See related
    Ensembl:ENSG00000116667 AllianceGenome:HGNC:15494
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PIG13
    Expression
    Ubiquitous expression in skin (RPKM 14.5), brain (RPKM 10.8) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See C1orf21 in Genome Data Viewer
    Location:
    1q25.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (184387029..184629019)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (183750271..183992246)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (184356163..184598153)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 654, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:184332598-184333098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:184333099-184333599 Neighboring gene NANOG hESC enhancer GRCh37_chr1:184350504-184351220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1637 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1639 Neighboring gene C1orf21 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2234 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:184489382-184489943 Neighboring gene tRNA methyltransferase 2 homolog B (S. cerevisiae) pseudogene Neighboring gene uncharacterized LOC107985236 Neighboring gene uncharacterized LOC124904468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2235 Neighboring gene uncharacterized LOC105371648

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. Sood R, et al. Genomics, 2001 Apr 15. PMID 11318611
    2. Super-resolution proximity labeling reveals anti-viral protein network and its structural changes against SARS-CoV-2 viral proteins. Lee YB, et al. Cell Rep, 2023 Aug 29. PMID 37478010
    3. Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma. Miller SG, et al. Mol Biol Cell, 2024 Mar 1. PMID 38117590, Free PMC Article
    4. A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy. El Zawily A, et al. Clin Cancer Res, 2023 Jul 14. PMID 36976175, Free PMC Article
    5. Large-scale concatenation cDNA sequencing. Yu W, et al. Genome Res, 1997 Apr. PMID 9110174, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein C1orf21
    Names
    cell proliferation-inducing gene 13 protein
    proliferation-inducing protein 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030806.4 → NP_110433.1  uncharacterized protein C1orf21

      See identical proteins and their annotated locations for NP_110433.1

      Status: VALIDATED

      Source sequence(s)
      AF312864, AK056487, AL358152, AY258286, BM793961
      Consensus CDS
      CCDS1362.1
      UniProtKB/Swiss-Prot
      B2R551, Q9H246
      Related
      ENSP00000235307.6, ENST00000235307.7
      Conserved Domains (1) summary
      pfam15389
      Location:2 → 118
      DUF4612; Domain of unknown function (DUF4612)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      184387029..184629019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      183750271..183992246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H246.1 GenPept UniProtKB/Swiss-Prot:Q9H246

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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