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    ABD1 mRNA (guanine-N7)-methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852538, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ABD1
    Official Full Name
    mRNA (guanine-N7)-methyltransferase
    Primary source
    SGD:S000000440
    Locus tag
    YBR236C
    See related
    AllianceGenome:SGD:S000000440; FungiDB:YBR236C; VEuPathDB:YBR236C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping. Located in cytosol and nucleus. Orthologous to human RNMT (RNA guanine-7 methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ABD1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (690383..691693, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Arc40p Neighboring gene Vhc1p Neighboring gene DEAD-box RNA helicase PRP5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene. Mao X, et al. Mol Cell Biol, 1995 Aug. PMID 7623811, Free PMC Article
    2. Yeast-based genetic system for functional analysis of poxvirus mRNA cap methyltransferase. Saha N, et al. J Virol, 2003 Jul. PMID 12805428, Free PMC Article
    3. A function of yeast mRNA cap methyltransferase, Abd1, in transcription by RNA polymerase II. Schroeder SC, et al. Mol Cell, 2004 Feb 13. PMID 14967145
    4. Poxvirus mRNA cap methyltransferase. Bypass of the requirement for the stimulatory subunit by mutations in the catalytic subunit and evidence for intersubunit allostery. Schwer B, et al. J Biol Chem, 2006 Jul 14. PMID 16707499
    5. Genetic analysis of poxvirus mRNA cap methyltransferase: suppression of conditional mutations in the stimulatory D12 subunit by second-site mutations in the catalytic D1 subunit. Schwer B, et al. Virology, 2006 Aug 15. PMID 16716374

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The histone chaperone Spt6 is required for normal recruitment of the capping enzyme Abd1 to transcribed regions.
      Title: The histone chaperone Spt6 is required for normal recruitment of the capping enzyme Abd1 to transcribed regions.
    2. Data show that the early Pol II elongation factor Spt5 contributes to stable recruitment of the mRNA capping enzymes Cet1, Ceg1, and Abd1 in the initiation-elongation transition of RNA polymerase II.
      Title: Cap completion and C-terminal repeat domain kinase recruitment underlie the initiation-elongation transition of RNA polymerase II.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 7-methylguanosine mRNA capping IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 7-methylguanosine mRNA capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA 5'-cap (guanine-N7)-methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mRNA (guanine-N7)-methyltransferase
    NP_009795.3
    • Methyltransferase; catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA; nuclear protein that relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      690383..691693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178584.3 → NP_009795.3  TPA: mRNA (guanine-N7)-methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009795.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQN2, P32783, Q6B2G0
      UniProtKB/TrEMBL
      A6ZLH5, B5VEI5, C7GMR7, D3UEY4, G2W9N9
      Conserved Domains (1) summary
      pfam03291
      Location:109 → 424
      Pox_MCEL; mRNA capping enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32783.1

    Gene LinkOut

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