Gpbar1 G protein-coupled bile acid receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpbar1provided by MGI
Official Full Name: G protein-coupled bile acid receptor 1provided by MGI
Primary source: MGI:MGI:2653863
See related: Ensembl:ENSMUSG00000064272 AllianceGenome:MGI:2653863
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BG37; GPCR; TGR5; M-BAR; GPR131
Summary: Predicted to enable G protein-coupled bile acid receptor activity. Involved in regulation of bicellular tight junction assembly. Predicted to be located in cytoplasm. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in gut and male reproductive gland or organ. Orthologous to human GPBAR1 (G protein-coupled bile acid receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 1 C3; 1 38.53 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (74316269..74318868)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (74278600..74279589)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The bile acid receptor TGR5 inhibits platelet activation and thrombus formation.
Title: The bile acid receptor TGR5 inhibits platelet activation and thrombus formation.
Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy.
Title: Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy.
Gpbar-1/cAMP/PKA signaling mitigates macrophage-mediated acute cholestatic liver injury via antagonizing NLRP3-ASC inflammasome.
Title: Gpbar-1/cAMP/PKA signaling mitigates macrophage-mediated acute cholestatic liver injury via antagonizing NLRP3-ASC inflammasome.
TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male mice.
Title: TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male mice.
Gut microbiota-mediated ursodeoxycholic acids regulate the inflammation of microglia through TGR5 signaling after MCAO.
Title: Gut microbiota-mediated ursodeoxycholic acids regulate the inflammation of microglia through TGR5 signaling after MCAO.
Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease.
Title: Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease.
The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy.
Title: The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy.
Activation of the bile acid receptors TGR5 and FXR in the spinal dorsal horn alleviates neuropathic pain.
Title: Activation of the bile acid receptors TGR5 and FXR in the spinal dorsal horn alleviates neuropathic pain.
Tgr5-/- mice are protected from ethanol-induced metabolic alterations through enhanced leptin and Fgf21 signaling.
Title: Tgr5-/- mice are protected from ethanol-induced metabolic alterations through enhanced leptin and Fgf21 signaling.
GPBAR1 preserves neurite and synapse of dopaminergic neurons via RAD21-OPCML signaling: Role in preventing Parkinson's disease in mouse model and human patients.
Title: GPBAR1 preserves neurite and synapse of dopaminergic neurons via RAD21-OPCML signaling: Role in preventing Parkinson's disease in mouse model and human patients.

Submit: New GeneRIF Correction See all GeneRIFs (91)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled bile acid receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled bile acid receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled bile acid receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to bile acid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to bile acid	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholangiocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cholangiocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of bicellular tight junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G-protein coupled bile acid receptor 1

Names: G protein-coupled receptor TGR5; membrane bile acid receptor; membrane-type receptor for bile acids

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.