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    Rhd Rh blood group, D antigen [ Mus musculus (house mouse) ]

    Gene ID: 19746, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rhdprovided by MGI
    Official Full Name
    Rh blood group, D antigenprovided by MGI
    Primary source
    MGI:MGI:1202882
    See related
    Ensembl:ENSMUSG00000028825 AllianceGenome:MGI:1202882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rh; Rhl1; Rhced
    Summary
    Predicted to enable ammonium channel activity. Acts upstream of or within ammonium transmembrane transport; erythrocyte development; and multicellular organismal-level iron ion homeostasis. Located in membrane. Is expressed in several structures, including gonad; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Rh isoimmunization. Orthologous to human RHCE (Rh blood group CcEe antigens) and RHD (Rh blood group D antigen). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E14.5 (RPKM 179.9), liver E14 (RPKM 141.9) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rhd in Genome Data Viewer
    Location:
    4 D3; 4 67.13 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134591875..134623483)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134864536..134896172)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor adaptor protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E3527 Neighboring gene STARR-seq mESC enhancer starr_11687 Neighboring gene STARR-seq mESC enhancer starr_11688 Neighboring gene macoilin 1 Neighboring gene STARR-positive B cell enhancer ABC_E2718 Neighboring gene STARR-positive B cell enhancer ABC_E4682 Neighboring gene STARR-seq mESC enhancer starr_11693 Neighboring gene transmembrane protein 50A Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:134474397-134474585 Neighboring gene STARR-positive B cell enhancer ABC_E6231 Neighboring gene STARR-positive B cell enhancer ABC_E8812 Neighboring gene arginine/serine rich protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the mouse Rh blood group gene. Westhoff CM, et al. Genomics, 1999 May 1. PMID 10329015
    2. Sequences and evolution of mammalian RH gene transcripts and proteins. Apoil P, et al. Immunogenetics, 1999 Jan. PMID 9811965
    3. The members of the RH gene family (RH50 and RH30) followed different evolutionary pathways. Matassi G, et al. J Mol Evol, 1999 Feb. PMID 9929383
    4. Generation and characterisation of Rhd and Rhag null mice. Goossens D, et al. Br J Haematol, 2010 Jan. PMID 19807729
    5. Evolutionary history of the Rh blood group-related genes in vertebrates. Kitano T, et al. Immunogenetics, 2000 Aug. PMID 10970100

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ammonium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ammonium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ammonium homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ammonium transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ammonium transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within erythrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ankyrin-1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    blood group Rh(D) polypeptide
    Names
    Rh blood group protein
    Rh-like polypeptide
    Rhesus blood group CE and D
    erythrocyte membrane glycoprotein Rh30

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011270.4 → NP_035400.3  blood group Rh(D) polypeptide

      Status: VALIDATED

      Source sequence(s)
      AL611963
      Consensus CDS
      CCDS18778.1
      UniProtKB/Swiss-Prot
      O88296, O88297, Q8CF94, Q9QUM6, Q9QX04
      UniProtKB/TrEMBL
      A0A0R4J0A2
      Related
      ENSMUSP00000030627.8, ENSMUST00000030627.8
      Conserved Domains (1) summary
      cl03012
      Location:53 → 393
      Ammonium_transp; Ammonium Transporter Family

    RNA

    1. NR_188963.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL611963

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      134591875..134623483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CF94.1 GenPept UniProtKB/Swiss-Prot:Q8CF94

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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