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    Doc2g double C2, gamma [ Mus musculus (house mouse) ]

    Gene ID: 60425, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Doc2gprovided by MGI
    Official Full Name
    double C2, gammaprovided by MGI
    Primary source
    MGI:MGI:1926250
    See related
    Ensembl:ENSMUSG00000024871 AllianceGenome:MGI:1926250
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D830013O18Rik
    Summary
    Predicted to enable metal ion binding activity. Acts upstream of or within spontaneous neurotransmitter secretion. Predicted to be located in membrane and presynapse. Predicted to be active in synapse. Is expressed in central nervous system and retina. Orthologous to human DOC2GP (double C2 domain gamma, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in heart adult (RPKM 156.3), frontal lobe adult (RPKM 65.6) and 1 other tissue See more
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    Genomic context

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    See Doc2g in Genome Data Viewer
    Location:
    19 A; 19 3.72 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4053385..4057005)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4003385..4007005)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene T-box 10 Neighboring gene nudix hydrolase 8 Neighboring gene NADH:ubiquinone oxidoreductase core subunit V1 Neighboring gene STARR-positive B cell enhancer ABC_E2517 Neighboring gene glutathione S-transferase, pi 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Doc2gamma, a third isoform of double C2 protein, lacking calcium-dependent phospholipid binding activity. Fukuda M, et al. Biochem Biophys Res Commun, 2000 Sep 24. PMID 11027523
    2. Ca(2+) sensor proteins in spontaneous release and synaptic plasticity: Limited contribution of Doc2c, rabphilin-3a and synaptotagmin 7 in hippocampal glutamatergic neurons. Bourgeois-Jaarsma Q, et al. Mol Cell Neurosci, 2021 Apr. PMID 33753311
    3. Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism. Pang ZP, et al. Neuron, 2011 Apr 28. PMID 21521611, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Readthrough Gm49405

    Readthrough gene: Gm49405, Included gene: Nudt8

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-dependent activation of synaptic vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spontaneous neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    double C2-like domain-containing protein gamma
    Names
    doc2-gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021791.3 → NP_068563.2  double C2-like domain-containing protein gamma

      See identical proteins and their annotated locations for NP_068563.2

      Status: VALIDATED

      Source sequence(s)
      BC061104
      Consensus CDS
      CCDS29409.1
      UniProtKB/Swiss-Prot
      Q6P8R8, Q9ESN1
      UniProtKB/TrEMBL
      A0A0R4J053
      Related
      ENSMUSP00000025806.4, ENSMUST00000025806.5
      Conserved Domains (2) summary
      cd04035
      Location:84 → 209
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cl14603
      Location:246 → 378
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4053385..4057005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ESN1.1 GenPept UniProtKB/Swiss-Prot:Q9ESN1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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