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    Phldb1 pleckstrin homology like domain, family B, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 102693, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Phldb1provided by MGI
    Official Full Name
    pleckstrin homology like domain, family B, member 1provided by MGI
    Primary source
    MGI:MGI:2143230
    See related
    Ensembl:ENSMUSG00000048537 AllianceGenome:MGI:2143230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ll5a; Ll5alpha; D330037A14Rik
    Summary
    Predicted to be involved in regulation of embryonic development; regulation of epithelial to mesenchymal transition; and regulation of microtubule cytoskeleton organization. Predicted to be located in several cellular components, including cytosol; intercellular bridge; and plasma membrane. Predicted to be active in basal cortex. Human ortholog(s) of this gene implicated in osteogenesis imperfecta. Orthologous to human PHLDB1 (pleckstrin homology like domain family B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 25.4), subcutaneous fat pad adult (RPKM 24.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Phldb1 in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44597605..44649800, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44686308..44735248, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC049987 Neighboring gene trehalase (brush-border membrane glycoprotein) Neighboring gene predicted gene, 24166 Neighboring gene archain 1 Neighboring gene STARR-positive B cell enhancer ABC_E9756 Neighboring gene intraflagellar transport 46

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of human LL5A gene and mouse Ll5a gene in silico. Katoh M, et al. Int J Oncol, 2003 Nov. PMID 14532993
    2. A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes. Zhou QL, et al. J Biol Chem, 2010 Sep 3. PMID 20587420, Free PMC Article
    3. Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. Kerns RT, et al. J Neurosci, 2005 Mar 2. PMID 15745951, Free PMC Article
    4. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
    5. Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice. Lenihan JA, et al. Mol Neurobiol, 2017 Dec. PMID 27889896

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PHLDB1 is a novel modulator of Akt protein kinase activation by insulin.
      Title: A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC32394

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gastrulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basal cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basal cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology-like domain family B member 1
    Names
    protein LL5-alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413419.1 → NP_001400348.1  pleckstrin homology-like domain family B member 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC142113, AC151971
      UniProtKB/TrEMBL
      D3Z4N0

    2. NM_001413420.1 → NP_001400349.1  pleckstrin homology-like domain family B member 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC142113, AC151971
      UniProtKB/TrEMBL
      D3Z0X5
      Related
      ENSMUSP00000120208.2, ENSMUST00000138356.8

    3. NM_001413421.1 → NP_001400350.1  pleckstrin homology-like domain family B member 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC142113, AC151971
      UniProtKB/TrEMBL
      D3Z4N0

    4. NM_001413422.1 → NP_001400351.1  pleckstrin homology-like domain family B member 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z0X5

    5. NM_001413423.1 → NP_001400352.1  pleckstrin homology-like domain family B member 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC142113, AC151971
      UniProtKB/TrEMBL
      D3Z4N0

    6. NM_001413424.1 → NP_001400353.1  pleckstrin homology-like domain family B member 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z0X5

    7. NM_001413425.1 → NP_001400354.1  pleckstrin homology-like domain family B member 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z0X5

    8. NM_001413426.1 → NP_001400355.1  pleckstrin homology-like domain family B member 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z0X5

    9. NM_001413427.1 → NP_001400356.1  pleckstrin homology-like domain family B member 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC142113, AC151971
      UniProtKB/TrEMBL
      D3Z4N0

    10. NM_001413428.1 → NP_001400357.1  pleckstrin homology-like domain family B member 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z0X5

    11. NM_001413429.1 → NP_001400358.1  pleckstrin homology-like domain family B member 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z0X5

    12. NM_001413430.1 → NP_001400359.1  pleckstrin homology-like domain family B member 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z0X5

    13. NM_001413431.1 → NP_001400360.1  pleckstrin homology-like domain family B member 1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC142113, AC151971
      UniProtKB/TrEMBL
      D3Z4N0

    14. NM_001413432.1 → NP_001400361.1  pleckstrin homology-like domain family B member 1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z4N0

    15. NM_001413433.1 → NP_001400362.1  pleckstrin homology-like domain family B member 1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC142113, AC151971
      UniProtKB/TrEMBL
      D3Z4N0

    16. NM_001413434.1 → NP_001400363.1  pleckstrin homology-like domain family B member 1 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z0X5

    17. NM_001413435.1 → NP_001400364.1  pleckstrin homology-like domain family B member 1 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z0X5

    18. NM_001413436.1 → NP_001400365.1  pleckstrin homology-like domain family B member 1 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC142113, AC151971
      UniProtKB/TrEMBL
      D3Z4N0, E9PWB1
      Related
      ENSMUSP00000117395.2, ENSMUST00000134465.8

    19. NM_001413437.1 → NP_001400366.1  pleckstrin homology-like domain family B member 1 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z0X5

    20. NM_001413438.1 → NP_001400367.1  pleckstrin homology-like domain family B member 1 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z0X5

    21. NM_001413439.1 → NP_001400368.1  pleckstrin homology-like domain family B member 1 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z0X5

    22. NM_001413440.1 → NP_001400369.1  pleckstrin homology-like domain family B member 1 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z0X5

    23. NM_001413441.1 → NP_001400370.1  pleckstrin homology-like domain family B member 1 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z4N0

    24. NM_001413442.1 → NP_001400371.1  pleckstrin homology-like domain family B member 1 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z4N0

    25. NM_001413443.1 → NP_001400372.1  pleckstrin homology-like domain family B member 1 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z0X5

    26. NM_001413444.1 → NP_001400373.1  pleckstrin homology-like domain family B member 1 isoform 23

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z0X5

    27. NM_001413445.1 → NP_001400374.1  pleckstrin homology-like domain family B member 1 isoform 24

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z0X5

    28. NM_001413446.1 → NP_001400375.1  pleckstrin homology-like domain family B member 1 isoform 25

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z4N0

    29. NM_001413447.1 → NP_001400376.1  pleckstrin homology-like domain family B member 1 isoform 26

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z4N0

    30. NM_001413448.1 → NP_001400377.1  pleckstrin homology-like domain family B member 1 isoform 27

      Status: VALIDATED

      Source sequence(s)
      AC142113, AC151971
      UniProtKB/TrEMBL
      D3Z4N0

    31. NM_001413449.1 → NP_001400378.1  pleckstrin homology-like domain family B member 1 isoform 28

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z4N0
      Related
      ENSMUSP00000121809.2, ENSMUST00000148344.8

    32. NM_001413450.1 → NP_001400379.1  pleckstrin homology-like domain family B member 1 isoform 28

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z4N0

    33. NM_001413451.1 → NP_001400380.1  pleckstrin homology-like domain family B member 1 isoform 30

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z0X5

    34. NM_001413452.1 → NP_001400381.1  pleckstrin homology-like domain family B member 1 isoform 31

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z4N0

    35. NM_001413453.1 → NP_001400382.1  pleckstrin homology-like domain family B member 1 isoform 32

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z4N0

    36. NM_001413454.1 → NP_001400383.1  pleckstrin homology-like domain family B member 1 isoform 33

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z4N0

    37. NM_001413455.1 → NP_001400384.1  pleckstrin homology-like domain family B member 1 isoform 34

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z4N0

    38. NM_001413456.1 → NP_001400385.1  pleckstrin homology-like domain family B member 1 isoform 35

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      D3Z4N0

    39. NM_001413457.1 → NP_001400386.1  pleckstrin homology-like domain family B member 1 isoform 36

      Status: VALIDATED

      Source sequence(s)
      AC151971
      UniProtKB/TrEMBL
      E9PWW4, E9Q307
      Related
      ENSMUSP00000114773.2, ENSMUST00000144251.8

    40. NM_153537.5 → NP_705765.3  pleckstrin homology-like domain family B member 1 isoform 6

      See identical proteins and their annotated locations for NP_705765.3

      Status: VALIDATED

      Source sequence(s)
      AC142113, AC151971
      Consensus CDS
      CCDS23118.1
      UniProtKB/Swiss-Prot
      Q6PDH0, Q80TV2
      UniProtKB/TrEMBL
      D3Z4N0
      Related
      ENSMUSP00000034611.9, ENSMUST00000034611.15
      Conserved Domains (7) summary
      cd14673
      Location:1260 → 1364
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1263 → 1359
      PH; PH domain
      pfam00498
      Location:64 → 124
      FHA; FHA domain
      pfam14988
      Location:731 → 936
      DUF4515; Domain of unknown function (DUF4515)
      cd16269
      Location:778 → 791
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:717 → 902
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:719 → 806
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44597605..44649800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154520.1 → XP_036010413.1  pleckstrin homology-like domain family B member 1 isoform X28

      UniProtKB/TrEMBL
      D3Z4N0
      Conserved Domains (4) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1311 → 1426
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1001
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    2. XM_030243976.2 → XP_030099836.2  pleckstrin homology-like domain family B member 1 isoform X26

      UniProtKB/TrEMBL
      D3Z4N0
      Conserved Domains (4) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1322 → 1437
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1001
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    3. XM_030243975.2 → XP_030099835.2  pleckstrin homology-like domain family B member 1 isoform X24

      UniProtKB/TrEMBL
      D3Z4N0
      Conserved Domains (4) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1337 → 1452
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1001
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    4. XM_030243974.2 → XP_030099834.2  pleckstrin homology-like domain family B member 1 isoform X20

      UniProtKB/TrEMBL
      D3Z4N0
      Conserved Domains (4) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1358 → 1473
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1039
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    5. XM_036154514.1 → XP_036010407.1  pleckstrin homology-like domain family B member 1 isoform X19

      UniProtKB/TrEMBL
      D3Z4N0
      Conserved Domains (4) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1369 → 1473
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1039
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    6. XM_030243971.2 → XP_030099831.2  pleckstrin homology-like domain family B member 1 isoform X16

      UniProtKB/TrEMBL
      D3Z4N0
      Conserved Domains (4) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1384 → 1499
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1039
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    7. XM_036154511.1 → XP_036010404.1  pleckstrin homology-like domain family B member 1 isoform X11

      UniProtKB/TrEMBL
      D3Z0X5
      Conserved Domains (4) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1425 → 1529
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1001
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    8. XM_030243968.2 → XP_030099828.2  pleckstrin homology-like domain family B member 1 isoform X9

      UniProtKB/TrEMBL
      D3Z0X5
      Conserved Domains (4) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1425 → 1540
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1001
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    9. XM_036154510.1 → XP_036010403.1  pleckstrin homology-like domain family B member 1 isoform X10

      UniProtKB/TrEMBL
      D3Z0X5
      Conserved Domains (4) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1429 → 1533
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1001
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    10. XM_030243966.2 → XP_030099826.2  pleckstrin homology-like domain family B member 1 isoform X7

      UniProtKB/TrEMBL
      D3Z0X5
      Conserved Domains (4) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1440 → 1555
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1001
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    11. XM_036154517.1 → XP_036010410.1  pleckstrin homology-like domain family B member 1 isoform X23

      UniProtKB/TrEMBL
      D3Z4N0
      Conserved Domains (5) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1354 → 1458
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1034
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02463
      Location:787 → 1335
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    12. XM_030243973.2 → XP_030099833.2  pleckstrin homology-like domain family B member 1 isoform X18

      UniProtKB/TrEMBL
      D3Z4N0
      Conserved Domains (5) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1365 → 1480
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1034
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02463
      Location:787 → 1350
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    13. XM_036154515.1 → XP_036010408.1  pleckstrin homology-like domain family B member 1 isoform X21

      UniProtKB/TrEMBL
      D3Z4N0
      Conserved Domains (5) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1369 → 1473
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1034
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02463
      Location:787 → 1350
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    14. XM_030243972.2 → XP_030099832.2  pleckstrin homology-like domain family B member 1 isoform X17

      UniProtKB/TrEMBL
      D3Z4N0
      Conserved Domains (4) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1380 → 1495
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1034
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    15. XM_036154513.1 → XP_036010406.1  pleckstrin homology-like domain family B member 1 isoform X14

      UniProtKB/TrEMBL
      D3Z4N0
      Conserved Domains (5) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1401 → 1516
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1034
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02463
      Location:787 → 1382
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    16. XM_030243969.2 → XP_030099829.2  pleckstrin homology-like domain family B member 1 isoform X12

      UniProtKB/TrEMBL
      D3Z0X5
      Conserved Domains (5) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1412 → 1527
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1034
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02463
      Location:787 → 1397
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    17. XM_030243967.2 → XP_030099827.2  pleckstrin homology-like domain family B member 1 isoform X8

      UniProtKB/TrEMBL
      D3Z0X5
      Conserved Domains (5) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1427 → 1542
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1034
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02463
      Location:787 → 1412
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    18. XM_030243965.2 → XP_030099825.2  pleckstrin homology-like domain family B member 1 isoform X6

      UniProtKB/TrEMBL
      D3Z0X5
      Conserved Domains (4) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1457 → 1572
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1034
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    19. XM_030243964.2 → XP_030099824.2  pleckstrin homology-like domain family B member 1 isoform X5

      UniProtKB/TrEMBL
      D3Z0X5
      Conserved Domains (4) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1472 → 1576
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1034
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    20. XM_030243962.2 → XP_030099822.2  pleckstrin homology-like domain family B member 1 isoform X4

      UniProtKB/TrEMBL
      D3Z0X5
      Conserved Domains (4) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1483 → 1598
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1034
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    21. XM_030243956.2 → XP_030099816.2  pleckstrin homology-like domain family B member 1 isoform X3

      UniProtKB/TrEMBL
      D3Z0X5
      Conserved Domains (4) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1520 → 1624
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1034
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    22. XM_030243954.2 → XP_030099814.2  pleckstrin homology-like domain family B member 1 isoform X2

      UniProtKB/TrEMBL
      D3Z0X5
      Conserved Domains (4) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1520 → 1635
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1034
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    23. XM_030243953.2 → XP_030099813.2  pleckstrin homology-like domain family B member 1 isoform X1

      UniProtKB/TrEMBL
      D3Z0X5
      Conserved Domains (4) summary
      PHA03307
      Location:251 → 646
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1531 → 1635
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:743 → 1034
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00498
      Location:162 → 222
      FHA; FHA domain

    24. XM_030243980.2 → XP_030099840.1  pleckstrin homology-like domain family B member 1 isoform X38

      UniProtKB/TrEMBL
      D3Z4N0
      Conserved Domains (4) summary
      PHA03307
      Location:33 → 428
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:563 → 816
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1183 → 1298
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam02463
      Location:548 → 1164
      SMC_N; RecF/RecN/SMC N terminal domain

    25. XM_036154529.1 → XP_036010422.1  pleckstrin homology-like domain family B member 1 isoform X36

      UniProtKB/TrEMBL
      D3Z0X5
      Conserved Domains (4) summary
      PHA03307
      Location:33 → 428
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1194 → 1309
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:525 → 816
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam02463
      Location:569 → 1179
      SMC_N; RecF/RecN/SMC N terminal domain

    26. XM_030243979.2 → XP_030099839.1  pleckstrin homology-like domain family B member 1 isoform X30

      UniProtKB/TrEMBL
      D3Z0X5
      Conserved Domains (3) summary
      PHA03307
      Location:33 → 428
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1265 → 1380
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:566 → 825
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    27. XM_036154537.1 → XP_036010430.1  pleckstrin homology-like domain family B member 1 isoform X45

      UniProtKB/TrEMBL
      D3Z4N0
      Conserved Domains (3) summary
      PHA03307
      Location:33 → 428
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1104 → 1219
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:525 → 783
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    28. XM_036154535.1 → XP_036010428.1  pleckstrin homology-like domain family B member 1 isoform X43

      UniProtKB/TrEMBL
      D3Z4N0
      Conserved Domains (3) summary
      PHA03307
      Location:33 → 428
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1119 → 1234
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:525 → 783
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    29. XM_030243981.1 → XP_030099841.1  pleckstrin homology-like domain family B member 1 isoform X40

      UniProtKB/TrEMBL
      D3Z0X5
      Conserved Domains (3) summary
      PHA03307
      Location:33 → 428
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:595 → 783
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1166 → 1281
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

    30. XM_036154523.1 → XP_036010416.1  pleckstrin homology-like domain family B member 1 isoform X33

      UniProtKB/TrEMBL
      D3Z0X5
      Conserved Domains (3) summary
      PHA03307
      Location:33 → 428
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14673
      Location:1207 → 1322
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:525 → 783
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PDH0.1 GenPept UniProtKB/Swiss-Prot:Q6PDH0

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