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    Prl7c1 prolactin family 7, subfamily c, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 67505, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prl7c1provided by MGI
    Official Full Name
    prolactin family 7, subfamily c, member 1provided by MGI
    Primary source
    MGI:MGI:1914755
    See related
    Ensembl:ENSMUSG00000060738 AllianceGenome:MGI:1914755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ghd20; PLP-O; Prlpo; Prplo; 1600017N11Rik
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in ectoplacental cone; extraembryonic component; and placenta. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward placenta adult (RPKM 7.2) See more
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    Genomic context

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    See Prl7c1 in Genome Data Viewer
    Location:
    13 A3.1; 13 12.61 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27957583..27964829, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27773600..27780846, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prolactin pseudogene Neighboring gene prolactin family 7, subfamily d, member 1 Neighboring gene STARR-seq mESC enhancer starr_34017 Neighboring gene STARR-seq mESC enhancer starr_34018 Neighboring gene prolactin family 2, subfamily a, member 1 Neighboring gene Prolactin family 2, subfamily c, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prenatal methamphetamine exposure causes dysfunction in glucose metabolism and low birthweight. Doi M, et al. Front Endocrinol (Lausanne), 2022. PMID 36353228, Free PMC Article
    2. Intense light-elicited upregulation of miR-21 facilitates glycolysis and cardioprotection through Per2-dependent mechanisms. Bartman CM, et al. PLoS One, 2017. PMID 28448534, Free PMC Article
    3. miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta. Sharma A, et al. Dev Biol, 2019 May 1. PMID 30771304, Free PMC Article
    4. The mouse prolactin gene family locus. Wiemers DO, et al. Endocrinology, 2003 Jan. PMID 12488360
    5. Bridging sequence diversity and tissue-specific expression by DNA methylation in genes of the mouse prolactin superfamily. Hayakawa K, et al. Mamm Genome, 2012 Jun. PMID 22193412, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prolactin-7C1
    Names
    PRL-like protein O
    growth hormone d20
    placental prolactin-like protein O
    prolactin-like protein O

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368392.1 → NP_001355321.1  prolactin-7C1 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1 and encodes a shorter isoform (2) missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AK005486

    2. NM_026206.3 → NP_080482.1  prolactin-7C1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_080482.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK005486
      Consensus CDS
      CCDS26406.1
      UniProtKB/Swiss-Prot
      Q9CRB5
      UniProtKB/TrEMBL
      A0A0M6L0E8
      Related
      ENSMUSP00000072712.4, ENSMUST00000072943.5
      Conserved Domains (1) summary
      cd10288
      Location:31 → 242
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      27957583..27964829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516733.3 → XP_006516796.1  prolactin-7C1 isoform X1

      Conserved Domains (1) summary
      cd10288
      Location:30 → 241
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CRB5.1 GenPept UniProtKB/Swiss-Prot:Q9CRB5

    Gene LinkOut

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