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    Mup8 major urinary protein 8 [ Mus musculus (house mouse) ]

    Gene ID: 100041687, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mup8provided by MGI
    Official Full Name
    major urinary protein 8provided by MGI
    Primary source
    MGI:MGI:3709619
    See related
    Ensembl:ENSMUSG00000078687 AllianceGenome:MGI:3709619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mup5; Gm12809
    Summary
    Enables odorant binding activity and organic cyclic compound binding activity. Located in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward liver adult (RPKM 2578.0) See more
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    Genomic context

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    See Mup8 in Genome Data Viewer
    Location:
    4 B3; 4 32.83 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (60218620..60222645, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (60218620..60222565, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10396 Neighboring gene major urinary protein 2 Neighboring gene major urinary protein, pseudogene 2 Neighboring gene major urinary protein, pseudogene 3 Neighboring gene major urinary protein, pseudogene 29

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Butylated hydroxytoluene is a ligand of urinary proteins derived from female mice. Kwak J, et al. Chem Senses, 2011 Jun. PMID 21398415
    2. Zhx2 (zinc fingers and homeoboxes 2) regulates major urinary protein gene expression in the mouse liver. Jiang J, et al. J Biol Chem, 2017 Apr 21. PMID 28258223, Free PMC Article
    3. TRF2-mediated telomere protection is dispensable in pluripotent stem cells. Markiewicz-Potoczny M, et al. Nature, 2021 Jan. PMID 33239785, Free PMC Article
    4. Species specificity in major urinary proteins by parallel evolution. Logan DW, et al. PLoS One, 2008 Sep 25. PMID 18815613, Free PMC Article
    5. Identification of protein pheromones that promote aggressive behaviour. Chamero P, et al. Nature, 2007 Dec 6. PMID 18064011

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables odorant binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables odorant binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables organic cyclic compound binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    major urinary protein 8
    Names
    major urinary protein (Mup) gene family member
    major urinary protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347131.1 → NP_001334060.1  major urinary protein 8 precursor

      Status: VALIDATED

      Source sequence(s)
      AL772327
      Consensus CDS
      CCDS84740.1
      UniProtKB/TrEMBL
      A2AKN8, B0V388
      Related
      ENSMUSP00000092668.5, ENSMUST00000095058.5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      60218620..60222645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253011.2 → XP_030108871.1  major urinary protein 8 isoform X1

      UniProtKB/TrEMBL
      E9PVW0, E9Q831
      Related
      ENSMUSP00000128910.2, ENSMUST00000163931.8
      Conserved Domains (1) summary
      cd19428
      Location:23 → 172
      lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001134676.1: Suppressed sequence

      Description
      NM_001134676.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein
    Heading Accession and Version

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