Stk38l serine/threonine kinase 38 like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stk38lprovided by MGI
Official Full Name: serine/threonine kinase 38 likeprovided by MGI
Primary source: MGI:MGI:1922250
See related: Ensembl:ENSMUSG00000001630 AllianceGenome:MGI:1922250
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ndr2; Ndr54; 4930473A22Rik
Summary: Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in regulation of cellular component organization. Located in actin cytoskeleton and cytoplasm. Orthologous to human STK38L (serine/threonine kinase 38 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 3.6), frontal lobe adult (RPKM 3.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G3; 6 77.7 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (146626428..146680312)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (146724930..146778814)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation.
Title: LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation.
NDR1/2 functions as a physiological YAP1 kinase in the intestinal epithelium.
Title: NDR functions as a physiological YAP1 kinase in the intestinal epithelium.
Ndr2 is an interesting candidate gene for the regulation of structural processes in differentiating and mature neuronal cells.
Title: Neuronal functions of the novel serine/threonine kinase Ndr2.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in postsynapse organization	IEA Inferred from Electronic Annotation more info
involved_in postsynapse organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cellular component organization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase 38-like

Names: nuclear Dbf2-related kinase 2

NP_001333595.1

EC 2.7.11.1

NP_766322.1

EC 2.7.11.1

XP_006507090.2

EC 2.7.11.1

XP_006507092.1

EC 2.7.11.1

XP_006507094.1

EC 2.7.11.1

XP_006507095.1

EC 2.7.11.1

XP_017177049.1

EC 2.7.11.1

XP_030111217.1

EC 2.7.11.1

XP_030111218.1

EC 2.7.11.1

XP_030111220.1

EC 2.7.11.1

XP_036021983.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346666.1 → NP_001333595.1 serine/threonine-protein kinase 38-like isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which as a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK045971, AY223819, BE946381, BY434134, CJ082246

UniProtKB/Swiss-Prot

Q7TSE6

Conserved Domains (1) summary

cl21453
Location:1 → 335

PKc_like; Protein Kinases, catalytic domain
NM_172734.3 → NP_766322.1 serine/threonine-protein kinase 38-like isoform 1

See identical proteins and their annotated locations for NP_766322.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC164631, AK052288, CJ082246

Consensus CDS

CCDS39712.1

UniProtKB/Swiss-Prot

B2KFR4, Q6P6K6, Q7TSE6, Q8BWK4

Related

ENSMUSP00000001675.8, ENSMUST00000001675.14

Conserved Domains (2) summary

smart00220
Location:90 → 383

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05627
Location:87 → 452

STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

146626428..146680312

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507027.2 → XP_006507090.2 serine/threonine-protein kinase 38-like isoform X1

See identical proteins and their annotated locations for XP_006507090.2

UniProtKB/Swiss-Prot

Q7TSE6

Related

ENSMUSP00000107271.2, ENSMUST00000111644.2

Conserved Domains (1) summary

cd05627
Location:87 → 459

STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2
XM_036166090.1 → XP_036021983.1 serine/threonine-protein kinase 38-like isoform X2

Conserved Domains (1) summary

cl21453
Location:87 → 391

PKc_like; Protein Kinases, catalytic domain
XM_006507032.4 → XP_006507095.1 serine/threonine-protein kinase 38-like isoform X7

See identical proteins and their annotated locations for XP_006507095.1

Conserved Domains (1) summary

cl21453
Location:1 → 342

PKc_like; Protein Kinases, catalytic domain
XM_030255358.2 → XP_030111218.1 serine/threonine-protein kinase 38-like isoform X6

Conserved Domains (1) summary

cd05627
Location:35 → 400

STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2
XM_006507031.3 → XP_006507094.1 serine/threonine-protein kinase 38-like isoform X5

See identical proteins and their annotated locations for XP_006507094.1

Conserved Domains (1) summary

cd05627
Location:35 → 407

STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2
XM_017321560.3 → XP_017177049.1 serine/threonine-protein kinase 38-like isoform X8

Conserved Domains (1) summary

cl21453
Location:1 → 335

PKc_like; Protein Kinases, catalytic domain
XM_030255360.2 → XP_030111220.1 serine/threonine-protein kinase 38-like isoform X7

Conserved Domains (1) summary

cl21453
Location:1 → 342

PKc_like; Protein Kinases, catalytic domain
XM_030255357.2 → XP_030111217.1 serine/threonine-protein kinase 38-like isoform X4

Conserved Domains (1) summary

cd05627
Location:93 → 458

STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2
XM_006507029.5 → XP_006507092.1 serine/threonine-protein kinase 38-like isoform X3

See identical proteins and their annotated locations for XP_006507092.1

Conserved Domains (1) summary

cd05627
Location:93 → 465

STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2