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    Adam29 a disintegrin and metallopeptidase domain 29 [ Mus musculus (house mouse) ]

    Gene ID: 244486, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adam29provided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 29provided by MGI
    Primary source
    MGI:MGI:2676326
    See related
    Ensembl:ENSMUSG00000046258 AllianceGenome:MGI:2676326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. [provided by RefSeq, May 2016]
    Expression
    Restricted expression toward testis adult (RPKM 7.0) See more
    Orthologs
    human all
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    Genomic context

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    See Adam29 in Genome Data Viewer
    Location:
    8 B2; 8 29.68 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (56323947..56359999, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (55870912..55906964, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36453 Neighboring gene STARR-seq mESC enhancer starr_21507 Neighboring gene STARR-seq mESC enhancer starr_21508 Neighboring gene STARR-seq mESC enhancer starr_21509 Neighboring gene STARR-seq mESC enhancer starr_21510 Neighboring gene methyltransferase like 13 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21511 Neighboring gene glycine receptor, alpha 3 subunit Neighboring gene ribosomal protein S7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21512 Neighboring gene STARR-seq mESC enhancer starr_21513 Neighboring gene STARR-seq mESC enhancer starr_21514 Neighboring gene STARR-seq mESC enhancer starr_21515 Neighboring gene STARR-seq mESC enhancer starr_21516 Neighboring gene hydroxyprostaglandin dehydrogenase 15 (NAD)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of ADAM29 does not affect viability and fertility in mice but improves wound healing. Campos-Iglesias D, et al. iScience, 2024 Jun 21. PMID 38966569, Free PMC Article
    2. Characterization and comparative genomic analysis of intronless Adams with testicular gene expression. Choi I, et al. Genomics, 2004 Apr. PMID 15028286
    3. Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice. Han C, et al. Biol Reprod, 2009 May. PMID 19129510
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm head plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm head plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 29
    Names
    a disintegrin and metalloprotease domain 29
    a disintegrin and metalloproteinase domain 29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175939.3 → NP_787953.2  disintegrin and metalloproteinase domain-containing protein 29 preproprotein

      See identical proteins and their annotated locations for NP_787953.2

      Status: VALIDATED

      Source sequence(s)
      AC158951, BB614467
      Consensus CDS
      CCDS22311.1
      UniProtKB/Swiss-Prot
      Q811Q4
      UniProtKB/TrEMBL
      G3X9B5
      Related
      ENSMUSP00000054292.5, ENSMUST00000053441.5
      Conserved Domains (5) summary
      smart00608
      Location:489 → 624
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:205 → 391
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:412 → 484
      Disintegrin; Disintegrin
      pfam01421
      Location:205 → 391
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:58 → 158
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      56323947..56359999 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q811Q4.1 GenPept UniProtKB/Swiss-Prot:Q811Q4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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