Ifnlr1 interferon lambda receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifnlr1provided by MGI
Official Full Name: interferon lambda receptor 1provided by MGI
Primary source: MGI:MGI:2429859
See related: Ensembl:ENSMUSG00000062157 AllianceGenome:MGI:2429859
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il28ra; CRF2-12
Summary: Predicted to enable cytokine receptor activity. Involved in defense response to virus and mucosal immune response. Predicted to be part of interleukin-28 receptor complex. Predicted to be active in plasma membrane. Is expressed in epidermis; gut; lower urinary tract; sensory organ; and submandibular gland primordium. Orthologous to human IFNLR1 (interferon lambda receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in large intestine adult (RPKM 4.4), small intestine adult (RPKM 4.1) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 67.94 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (135413513..135435492)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (135686457..135708181)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of Interferon Lambda Receptor Elucidates Susceptibility to the Murine Model of Biliary Atresia.
Title: Deletion of Interferon Lambda Receptor Elucidates Susceptibility to the Murine Model of Biliary Atresia.
Interferon Lambda Signals in Maternal Tissues to Exert Protective and Pathogenic Effects in a Gestational Stage-Dependent Manner.
Title: Interferon Lambda Signals in Maternal Tissues to Exert Protective and Pathogenic Effects in a Gestational Stage-Dependent Manner.
Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium.
Title: Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium.
B cell intrinsic expression of IFNlambda receptor suppresses the acute humoral immune response to experimental blood-stage malaria.
Title: B cell intrinsic expression of IFNλ receptor suppresses the acute humoral immune response to experimental blood-stage malaria.
Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells.
Title: Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells.
Mice lacking the IFN-lambda receptor (Ifnlr1(-/-)) had blunted CD8(+) T cell responses relative to wild type and exhibited reduced survival after heterosubtypic influenza A virus re-challenge.
Title: Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus.
This study was designed to explore the genetic etiology of deafness in a large Chinese family with autosomal dominant, nonsyndromic, progressive sensorineural hearing loss (ADNSHL). Inner ear expression of Ifnlr1 was investigated by immunostaining in mice. ifnlr1 Morpholino knockdown Zebrafish were constructed to explore the deafness mechanism.. IFNLR1 mutations are associated with ADNSHL.
Title: Mutation of IFNLR1, an interferon lambda receptor 1, is associated with autosomal-dominant non-syndromic hearing loss.
Ifnlr1 is expressed in the epithelial fraction along the length of the gastrointestinal tract and is essential for induction of IFN-lambda-mediated sterilizing innate immunity to norovirus.
Title: Expression of Ifnlr1 on Intestinal Epithelial Cells Is Critical to the Antiviral Effects of Interferon Lambda against Norovirus and Reovirus.
interferon-lambda has a role in noncanonical signaling through IFNLR1, which tightens the blood-brain barrier and restricts viral neuroinvasion and pathogenesis
Title: Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier.
Rotavirus infection induces production of IFN-lambda by IECs and of IL-22 by ILC3 cells.
Title: Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9) 1 citation
Targeted (6) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to virus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mucosal immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular respiration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cellular respiration	ISO Inferred from Sequence Orthology more info
involved_in regulation of defense response to virus by host	IEA Inferred from Electronic Annotation more info
involved_in regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in response to type III interferon	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of interleukin-28 receptor complex	IEA Inferred from Electronic Annotation more info
part_of interleukin-28 receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interferon lambda receptor 1

Names: IFN-lambda R1; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; class II cytokine receptor 12; cytokine receptor class-II member 12; cytokine receptor family 2 member 12; interleukin 28 receptor alpha; interleukin-28 receptor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.