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    Hnrnpa0 heterogeneous nuclear ribonucleoprotein A0 [ Mus musculus (house mouse) ]

    Gene ID: 77134, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hnrnpa0provided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein A0provided by MGI
    Primary source
    MGI:MGI:1924384
    See related
    Ensembl:ENSMUSG00000007836 AllianceGenome:MGI:1924384
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hnrpa0; hnRNP A0; 1110055B05Rik; 3010025E17Rik
    Summary
    Enables mRNA 3'-UTR AU-rich region binding activity. Involved in 3'-UTR-mediated mRNA stabilization; inflammatory response; and response to lipopolysaccharide. Is active in synapse. Is expressed in 3rd ventricle; 4th ventricle; brain; brain ventricular layer; and telencephalon ventricular layer. Orthologous to human HNRNPA0 (heterogeneous nuclear ribonucleoprotein A0). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human all
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    Genomic context

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    See Hnrnpa0 in Genome Data Viewer
    Location:
    13 B1; 13 30.95 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (58273693..58276370, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (58125879..58128556, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene kelch-like 3 Neighboring gene predicted gene, 33389 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:58214590-58214824 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:58219145-58219254 Neighboring gene predicted gene, 52040 Neighboring gene STARR-positive B cell enhancer ABC_E7243 Neighboring gene STARR-seq mESC enhancer starr_34671 Neighboring gene predicted gene, 40964 Neighboring gene RIKEN cDNA 1700066J03 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts. Young DJ, et al. Haematologica, 2014 Jun. PMID 24532040, Free PMC Article
    2. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. Rousseau S, et al. EMBO J, 2002 Dec 2. PMID 12456657, Free PMC Article
    3. Distinct expression of select and transcriptome-wide isolated 3'UTRs suggests critical roles in development and transition states. Ji S, et al. PLoS One, 2021. PMID 33951080, Free PMC Article
    4. The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration. Slabber CF, et al. Sci Signal, 2023 May 30. PMID 37253089
    5. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts.
      Title: Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 3'-UTR-mediated mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein A0

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029872.1 → NP_084148.1  heterogeneous nuclear ribonucleoprotein A0

      See identical proteins and their annotated locations for NP_084148.1

      Status: VALIDATED

      Source sequence(s)
      AC165251
      Consensus CDS
      CCDS49280.1
      UniProtKB/Swiss-Prot
      Q9CX86
      Related
      ENSMUSP00000007980.7, ENSMUST00000007980.7
      Conserved Domains (3) summary
      pfam11627
      Location:253 → 272
      HnRNPA1; Nuclear factor hnRNPA1
      cd12326
      Location:5 → 83
      RRM1_hnRNPA0; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0) and similar proteins
      cl17169
      Location:99 → 178
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      58273693..58276370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CX86.1 GenPept UniProtKB/Swiss-Prot:Q9CX86

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools