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    Zfp869 zinc finger protein 869 [ Mus musculus (house mouse) ]

    Gene ID: 66869, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp869provided by MGI
    Official Full Name
    zinc finger protein 869provided by MGI
    Primary source
    MGI:MGI:1914119
    See related
    Ensembl:ENSMUSG00000054648 AllianceGenome:MGI:1914119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200003I07Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II and retrotransposon silencing. Predicted to be active in nucleus. Orthologous to human ZNF91 (zinc finger protein 91). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 7.8), CNS E11.5 (RPKM 7.2) and 28 other tissues See more
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    Genomic context

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    See Zfp869 in Genome Data Viewer
    Location:
    8 B3.3; 8 33.88 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70157787..70169718, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69705137..69717068, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 868 Neighboring gene STARR-positive B cell enhancer ABC_E9116 Neighboring gene STARR-positive B cell enhancer ABC_E453 Neighboring gene STARR-seq mESC enhancer starr_21742 Neighboring gene zinc finger protein 964 Neighboring gene STARR-positive B cell enhancer ABC_E9117 Neighboring gene STARR-positive B cell enhancer ABC_E242 Neighboring gene predicted gene, 51532 Neighboring gene STARR-positive B cell enhancer ABC_E6642 Neighboring gene zinc finger protein 963

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Altered levels of growth-related and novel gene transcripts in reproductive and other tissues of female mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT). Min SH, et al. J Biol Chem, 2002 Feb 1. PMID 11709547
    2. Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Aubert J, et al. Nat Biotechnol, 2002 Dec. PMID 12447396
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transposable element silencing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 869
    Names
    U 2-7-1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039965.1 → NP_001035054.1  zinc finger protein 869

      See identical proteins and their annotated locations for NP_001035054.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AK136878, AW495147, BY295637
      Consensus CDS
      CCDS40360.1
      UniProtKB/TrEMBL
      Q9DC47
      Related
      ENSMUSP00000158786.2, ENSMUST00000238418.2
      Conserved Domains (3) summary
      COG5048
      Location:177 → 510
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:182 → 202
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:15 → 56
      KRAB; KRAB box

    2. NM_001039967.1 → NP_001035056.1  zinc finger protein 869

      See identical proteins and their annotated locations for NP_001035056.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. All five variants encode the same protein.
      Source sequence(s)
      AK004570, AK030679, AW495147, BY295637
      Consensus CDS
      CCDS40360.1
      UniProtKB/TrEMBL
      Q9DC47
      Related
      ENSMUSP00000158615.2, ENSMUST00000238408.2
      Conserved Domains (3) summary
      COG5048
      Location:177 → 510
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:182 → 202
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:15 → 56
      KRAB; KRAB box

    3. NM_001359086.1 → NP_001346015.1  zinc finger protein 869

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AC157564, AW495147
      Consensus CDS
      CCDS40360.1
      UniProtKB/TrEMBL
      Q9DC47
      Conserved Domains (3) summary
      COG5048
      Location:177 → 510
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:182 → 202
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:15 → 56
      KRAB; KRAB box

    4. NM_001359087.1 → NP_001346016.1  zinc finger protein 869

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AC157564, AW495147
      Consensus CDS
      CCDS40360.1
      UniProtKB/TrEMBL
      Q9DC47
      Related
      ENSMUSP00000158663.2, ENSMUST00000238657.2
      Conserved Domains (3) summary
      COG5048
      Location:177 → 510
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:182 → 202
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:15 → 56
      KRAB; KRAB box

    5. NM_181274.4 → NP_851791.1  zinc finger protein 869

      See identical proteins and their annotated locations for NP_851791.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AC157564, AW495147
      Consensus CDS
      CCDS40360.1
      UniProtKB/TrEMBL
      Q9DC47
      Related
      ENSMUSP00000158827.2, ENSMUST00000238292.2
      Conserved Domains (3) summary
      COG5048
      Location:177 → 510
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:182 → 202
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:15 → 56
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70157787..70169718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242320.3 → XP_011240622.1  zinc finger protein 869 isoform X1

      See identical proteins and their annotated locations for XP_011240622.1

      UniProtKB/TrEMBL
      Q9DC47
      Conserved Domains (3) summary
      COG5048
      Location:177 → 510
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:182 → 202
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:15 → 56
      KRAB; KRAB box

    2. XM_030243731.2 → XP_030099591.1  zinc finger protein 869 isoform X1

      UniProtKB/TrEMBL
      Q9DC47
      Conserved Domains (3) summary
      COG5048
      Location:177 → 510
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:182 → 202
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:15 → 56
      KRAB; KRAB box

    3. XM_011242319.3 → XP_011240621.1  zinc finger protein 869 isoform X1

      See identical proteins and their annotated locations for XP_011240621.1

      UniProtKB/TrEMBL
      Q9DC47
      Conserved Domains (3) summary
      COG5048
      Location:177 → 510
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:182 → 202
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:15 → 56
      KRAB; KRAB box

    4. XM_011242318.3 → XP_011240620.1  zinc finger protein 869 isoform X1

      See identical proteins and their annotated locations for XP_011240620.1

      UniProtKB/TrEMBL
      Q9DC47
      Conserved Domains (3) summary
      COG5048
      Location:177 → 510
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:182 → 202
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:15 → 56
      KRAB; KRAB box
    Nucleotide Protein Strain
    Heading Accession and Version

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