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    CDKN2AIPNL CDKN2A interacting protein N-terminal like [ Homo sapiens (human) ]

    Gene ID: 91368, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CDKN2AIPNLprovided by HGNC
    Official Full Name
    CDKN2A interacting protein N-terminal likeprovided by HGNC
    Primary source
    HGNC:HGNC:30545
    See related
    Ensembl:ENSG00000237190 AllianceGenome:HGNC:30545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C2AIL
    Expression
    Ubiquitous expression in thyroid (RPKM 3.8), testis (RPKM 3.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CDKN2AIPNL in Genome Data Viewer
    Location:
    5q31.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (134402065..134411881, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (134925882..134938449, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (133737756..133747572, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S13 pseudogene 6 Neighboring gene MPRA-validated peak5475 silencer Neighboring gene cyclin dependent kinase like 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133680746-133681444 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133681445-133682144 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133706379-133706974 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23143 Neighboring gene ubiquitin conjugating enzyme E2 B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133746964-133747702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133747703-133748440 Neighboring gene MPRA-validated peak5476 silencer Neighboring gene ribosomal protein S10 pseudogene 11 Neighboring gene long intergenic non-protein coding RNA 2999

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis and function of XRN2 binding by XTB domains. Richter H, et al. Nat Struct Mol Biol, 2016 Feb. PMID 26779609, Free PMC Article
    2. Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress. Zhu X, et al. FASEB J, 2016 Feb. PMID 26472337
    3. Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth. Wisniewski DJ, et al. J Biol Chem, 2023 Jan. PMID 36470425, Free PMC Article
    4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. Li S, et al. Proc Natl Acad Sci U S A, 2014 May 13. PMID 24778252, Free PMC Article
    5. BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A. Mao CG, et al. Thorac Cancer, 2020 Nov. PMID 33001583, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC13017

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CDKN2AIP N-terminal-like protein
    Names
    CDKN2A-interacting protein N-terminal-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080656.3 → NP_542387.1  CDKN2AIP N-terminal-like protein

      See identical proteins and their annotated locations for NP_542387.1

      Status: VALIDATED

      Source sequence(s)
      BC008293, BM997508
      Consensus CDS
      CCDS4175.1
      UniProtKB/Swiss-Prot
      Q8WVE3, Q96HQ2
      Related
      ENSP00000394183.2, ENST00000458198.3
      Conserved Domains (1) summary
      pfam11952
      Location:25 → 113
      XTBD; XRN-Two Binding Domain, XTBD

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      134402065..134411881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      134925882..134938449 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353770.1 → XP_054209745.1  CDKN2AIP N-terminal-like protein isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96HQ2.1 GenPept UniProtKB/Swiss-Prot:Q96HQ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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