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    WWP1 WW domain containing E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

    Gene ID: 11059, updated on 3-Dec-2024

    Summary

    Official Symbol
    WWP1provided by HGNC
    Official Full Name
    WW domain containing E3 ubiquitin protein ligase 1provided by HGNC
    Primary source
    HGNC:HGNC:17004
    See related
    Ensembl:ENSG00000123124 MIM:602307; AllianceGenome:HGNC:17004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIP5; Tiul1; hSDRP1
    Summary
    WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in liver (RPKM 24.3), gall bladder (RPKM 23.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See WWP1 in Genome Data Viewer
    Location:
    8q21.3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (86342547..86468503)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (87462833..87588744)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (87354776..87480732)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375623 Neighboring gene solute carrier family 7 member 13 Neighboring gene HNF4 motif-containing MPRA enhancer 29 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19341 Neighboring gene WWP1 antisense RNA 1 Neighboring gene regulator of microtubule dynamics 1 Neighboring gene N-terminal asparagine amidase pseudogene 2 Neighboring gene solute carrier family 2 member 3 pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp434D2111

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ubiquitin ligase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    NEDD4-like E3 ubiquitin-protein ligase WWP1
    Names
    HECT-type E3 ubiquitin transferase WWP1
    Nedd-4-like ubiquitin-protein ligase
    TGIF-interacting ubiquitin ligase 1
    WW domain-containing protein 1
    atrophin-1 interacting protein 5
    NP_008944.1
    XP_005250817.1
    XP_005250818.1
    XP_016868482.1
    XP_016868483.1
    XP_024302824.1
    XP_047277238.1
    XP_047277239.1
    XP_047277240.1
    XP_047277241.1
    XP_054215606.1
    XP_054215607.1
    XP_054215608.1
    XP_054215609.1
    XP_054215610.1
    XP_054215611.1
    XP_054215612.1
    XP_054215613.1
    XP_054215614.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007013.4NP_008944.1  NEDD4-like E3 ubiquitin-protein ligase WWP1

      See identical proteins and their annotated locations for NP_008944.1

      Status: VALIDATED

      Source sequence(s)
      AC103760, AC103817, AW137654, AY043361, BC036065, BM664090
      Consensus CDS
      CCDS6242.1
      UniProtKB/Swiss-Prot
      O00307, Q5YLC1, Q96BP4, Q9H0M0
      UniProtKB/TrEMBL
      A8K9T5
      Related
      ENSP00000427793.1, ENST00000517970.6
      Conserved Domains (2) summary
      cd04021
      Location:17140
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      COG5021
      Location:307922
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      86342547..86468503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447056.2XP_024302824.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3

      UniProtKB/TrEMBL
      A8K9T5
      Conserved Domains (4) summary
      cd04021
      Location:17140
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      cd00078
      Location:559896
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:499528
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:351380
      WW; WW domain
    2. XM_005250761.5XP_005250818.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2

      UniProtKB/TrEMBL
      A8K9T5
      Conserved Domains (6) summary
      cd04021
      Location:17140
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      smart00119
      Location:590918
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:567919
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:498527
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:350379
      WW; WW domain
      pfam07010
      Location:201326
      Endomucin; Endomucin
    3. XM_047421282.1XP_047277238.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X4

      UniProtKB/TrEMBL
      A8K9T5
    4. XM_005250760.5XP_005250817.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1

      See identical proteins and their annotated locations for XP_005250817.1

      UniProtKB/Swiss-Prot
      O00307, Q5YLC1, Q96BP4, Q9H0M0
      UniProtKB/TrEMBL
      A8K9T5
      Related
      ENSP00000265428.4, ENST00000265428.4
      Conserved Domains (2) summary
      cd04021
      Location:17140
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      COG5021
      Location:307922
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    5. XM_017012994.3XP_016868483.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3

      UniProtKB/TrEMBL
      A8K9T5
      Conserved Domains (4) summary
      cd04021
      Location:17140
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      cd00078
      Location:559896
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:499528
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:351380
      WW; WW domain
    6. XM_017012993.2XP_016868482.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2

      UniProtKB/TrEMBL
      A8K9T5
      Conserved Domains (6) summary
      cd04021
      Location:17140
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      smart00119
      Location:590918
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:567919
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:498527
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:350379
      WW; WW domain
      pfam07010
      Location:201326
      Endomucin; Endomucin
    7. XM_047421283.1XP_047277239.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X4

      UniProtKB/TrEMBL
      A8K9T5
    8. XM_047421285.1XP_047277241.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X6

    9. XM_047421284.1XP_047277240.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X5

      UniProtKB/TrEMBL
      A8K9T5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      87462833..87588744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359634.1XP_054215609.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3

      UniProtKB/TrEMBL
      A8K9T5
    2. XM_054359632.1XP_054215607.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2

      UniProtKB/TrEMBL
      A8K9T5
    3. XM_054359636.1XP_054215611.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X4

      UniProtKB/TrEMBL
      A8K9T5
    4. XM_054359631.1XP_054215606.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1

      UniProtKB/Swiss-Prot
      O00307, Q5YLC1, Q96BP4, Q9H0M0
      UniProtKB/TrEMBL
      A8K9T5
    5. XM_054359635.1XP_054215610.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3

      UniProtKB/TrEMBL
      A8K9T5
    6. XM_054359633.1XP_054215608.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2

      UniProtKB/TrEMBL
      A8K9T5
    7. XM_054359637.1XP_054215612.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X4

      UniProtKB/TrEMBL
      A8K9T5
    8. XM_054359639.1XP_054215614.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X6

    9. XM_054359638.1XP_054215613.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X5

      UniProtKB/TrEMBL
      A8K9T5