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    RHOXF2 Rhox homeobox family member 2 [ Homo sapiens (human) ]

    Gene ID: 84528, updated on 27-Nov-2024

    Summary

    Official Symbol
    RHOXF2provided by HGNC
    Official Full Name
    Rhox homeobox family member 2provided by HGNC
    Primary source
    HGNC:HGNC:30011
    See related
    Ensembl:ENSG00000131721 MIM:300447; AllianceGenome:HGNC:30011
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    THG1; CT107; PEPP2; PEPP-2
    Summary
    This gene, which encodes a transcriptional repressor, is one of two paralogous X-linked homeobox-containing genes and is highly expressed in a variety of cancers. In addition, the encoded protein associates with the cell membrane and with microtubules, and is concentrated at the leading edge of migratory cells. [provided by RefSeq, Dec 2015]
    Expression
    Restricted expression toward testis (RPKM 22.1) See more
    Orthologs
    NEW
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    Genomic context

    See RHOXF2 in Genome Data Viewer
    Location:
    Xq24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (120158613..120165630)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (118533725..118540742)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (119292519..119299536)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RHOXF1 antisense RNA 1 Neighboring gene Rhox homeobox family member 2B Neighboring gene ReSE screen-validated silencer GRCh37_chrX:119254442-119254623 Neighboring gene Rhox homeobox family member 1 Neighboring gene long intergenic non-protein coding RNA 1402 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 30 Neighboring gene SFR1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    rhox homeobox family member 2
    Names
    PEPP subfamily gene 2
    cancer/testis antigen 107
    homeobox protein from AL590526
    paired-like homeobox protein PEPP-2
    testis homeobox gene 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032498.3NP_115887.1  rhox homeobox family member 2

      See identical proteins and their annotated locations for NP_115887.1

      Status: REVIEWED

      Source sequence(s)
      AC240549, AL590526, BC021719
      Consensus CDS
      CCDS14594.1
      UniProtKB/Swiss-Prot
      Q9BQY4, Q9BR00
      Related
      ENSP00000360441.3, ENST00000371388.5
      Conserved Domains (1) summary
      pfam00046
      Location:140190
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      120158613..120165630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      118533725..118540742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)