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    Pramex1 PRAME like, X-linked 1 [ Mus musculus (house mouse) ]

    Gene ID: 75829, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pramex1provided by MGI
    Official Full Name
    PRAME like, X-linked 1provided by MGI
    Primary source
    MGI:MGI:1923079
    See related
    Ensembl:ENSMUSG00000031411 AllianceGenome:MGI:1923079
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prame; 4930534P07Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 2.8) See more
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    Genomic context

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    See Pramex1 in Genome Data Viewer
    Location:
    X F1; X 57.26 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (134513662..134528437, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (135612954..135627705, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene preferentially expressed antigen in melanoma-like 3 pseudogene Neighboring gene nuclear RNA export factor 7 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene t-complex 11 family, X-linked 2 Neighboring gene STARR-seq mESC enhancer starr_47970 Neighboring gene thymosin beta 15a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of the mouse X-linked Prame gene causes germ cell reduction in spermatogenesis. Lu C, et al. Mol Reprod Dev, 2020 Jun. PMID 32017313
    2. The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling. Epping MT, et al. Cell, 2005 Sep 23. PMID 16179254
    3. A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice. Zhou J, et al. Biol Reprod, 2013 Jun. PMID 23677977, Free PMC Article
    4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of the mouse X-linked Prame gene causes germ cell reduction in spermatogenesis.
      Title: Deletion of the mouse X-linked Prame gene causes germ cell reduction in spermatogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    preferentially expressed antigen in melanoma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029459.3 → NP_083735.3  preferentially expressed antigen in melanoma

      Status: VALIDATED

      Source sequence(s)
      AL671911
      Consensus CDS
      CCDS53190.1
      UniProtKB/TrEMBL
      F7ADI6
      Related
      ENSMUSP00000108784.3, ENSMUST00000113159.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      134513662..134528437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318634.3 → XP_017174123.1  preferentially expressed antigen in melanoma isoform X1

      UniProtKB/TrEMBL
      Q9D4Z5
      Conserved Domains (2) summary
      sd00031
      Location:384 → 395
      LRR_1; leucine-rich repeat [structural motif]
      sd00034
      Location:213 → 240
      LRR_AMN1; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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