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    Baiap3 BAI1-associated protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 545192, updated on 3-Dec-2024

    Summary

    Official Symbol
    Baiap3provided by MGI
    Official Full Name
    BAI1-associated protein 3provided by MGI
    Primary source
    MGI:MGI:2685783
    See related
    Ensembl:ENSMUSG00000047507 AllianceGenome:MGI:2685783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bap3; Gm937
    Summary
    Predicted to enable calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in regulation of GABAergic synaptic transmission and regulation of behavior. Is active in GABA-ergic synapse. Is expressed in brain. Orthologous to human BAIAP3 (BAI1 associated protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 8.6), CNS E18 (RPKM 8.4) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Baiap3 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25461633..25475255, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25242659..25256364, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52286 Neighboring gene unkempt family like zinc finger Neighboring gene N-acetylglucosamine-1-phosphotransferase, gamma subunit Neighboring gene TSR3 20S rRNA accumulation Neighboring gene microRNA 3547 Neighboring gene ubiquitin-conjugating enzyme E2I Neighboring gene STARR-positive B cell enhancer ABC_E8659 Neighboring gene predicted gene, 17801 Neighboring gene serine protease 34

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SNARE binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dense core granule maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dense core granule maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neurotransmitter secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of dense core granule exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of dense core granule exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of dense core granule exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic transmission, GABAergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in secretory vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    BAI1-associated protein 3
    Names
    brain-specific angiogenesis inhibitor I-associated protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163270.2NP_001156742.1  BAI1-associated protein 3

      See identical proteins and their annotated locations for NP_001156742.1

      Status: VALIDATED

      Source sequence(s)
      AC122454
      Consensus CDS
      CCDS50033.1
      UniProtKB/Swiss-Prot
      E9QQ76, Q6RUT4, Q80TT2, S4R1E7
      UniProtKB/TrEMBL
      B2RY68
      Related
      ENSMUSP00000138188.2, ENSMUST00000182056.8
      Conserved Domains (3) summary
      cd04009
      Location:9731102
      C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins
      cd08676
      Location:131330
      C2A_Munc13-like; C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins
      pfam10540
      Location:852954
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    2. NM_001408206.1NP_001395135.1  BAI1-associated protein 3

      Status: VALIDATED

      Source sequence(s)
      AC122454
      UniProtKB/Swiss-Prot
      E9QQ76, Q6RUT4, Q80TT2, S4R1E7
      UniProtKB/TrEMBL
      B2RY68

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25461633..25475255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524643.5XP_006524706.1  BAI1-associated protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006524706.1

      UniProtKB/Swiss-Prot
      E9QQ76, Q6RUT4, Q80TT2, S4R1E7
      UniProtKB/TrEMBL
      B2RY68
      Conserved Domains (3) summary
      cd04009
      Location:9731102
      C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins
      cd08676
      Location:131330
      C2A_Munc13-like; C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins
      pfam10540
      Location:852954
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain