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    Arpc4 actin related protein 2/3 complex, subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 68089, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arpc4provided by MGI
    Official Full Name
    actin related protein 2/3 complex, subunit 4provided by MGI
    Primary source
    MGI:MGI:1915339
    See related
    Ensembl:ENSMUSG00000079426 AllianceGenome:MGI:1915339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    20kDa; p20-Arc; 5330419I20Rik
    Summary
    Predicted to enable actin filament binding activity and enzyme binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to protein-macromolecule adaptor activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in nucleus and site of double-strand break. Predicted to be part of Arp2/3 protein complex. Is expressed in dorsal root ganglion. Used to study psoriasis. Orthologous to human ARPC4 (actin related protein 2/3 complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 58.0), placenta adult (RPKM 48.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arpc4 in Genome Data Viewer
    Location:
    6 E3; 6 52.76 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113355074..113367408)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113378113..113390447)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma) pseudogene Neighboring gene transcriptional adaptor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:113327864-113328099 Neighboring gene tubulin tyrosine ligase-like family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1706 Neighboring gene RNA pseudouridylate synthase domain containing 3 Neighboring gene cell death-inducing DFFA-like effector c Neighboring gene predicted gene, 52871

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Aberrant cortex contractions impact mammalian oocyte quality. Nikalayevich E, et al. Dev Cell, 2024 Apr 8. PMID 38387459
    2. Knockout of the Arp2/3 complex in epidermis causes a psoriasis-like disease hallmarked by hyperactivation of transcription factor Nrf2. van der Kammen R, et al. Development, 2017 Dec 15. PMID 29113991
    3. Active cell migration is critical for steady-state epithelial turnover in the gut. Krndija D, et al. Science, 2019 Aug 16. PMID 31416964
    4. mTORC1 and mTORC2 Converge on the Arp2/3 Complex to Promote Kras(G12D)-Induced Acinar-to-Ductal Metaplasia and Early Pancreatic Carcinogenesis. Zhao Y, et al. Gastroenterology, 2021 Apr. PMID 33388318
    5. Endothelial cell invasion is controlled by dactylopodia. Figueiredo AM, et al. Proc Natl Acad Sci U S A, 2021 May 4. PMID 33903241, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Arp2/3 protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Arp2/3 protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of Arp2/3 protein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in site of double-strand break ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    actin-related protein 2/3 complex subunit 4
    Names
    arp2/3 complex 20 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170485.1 → NP_001163956.1  actin-related protein 2/3 complex subunit 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC155287, AK017993, AK133626
      Consensus CDS
      CCDS51871.1
      UniProtKB/TrEMBL
      E9PWA7
      Related
      ENSMUSP00000131690.2, ENSMUST00000171058.8
      Conserved Domains (1) summary
      cl05433
      Location:2 → 89
      ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)

    2. NM_001170486.1 → NP_001163957.1  actin-related protein 2/3 complex subunit 4 isoform 3

      See identical proteins and their annotated locations for NP_001163957.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC155287, AK017993, AK133626
      Consensus CDS
      CCDS85117.1
      UniProtKB/TrEMBL
      Q3TX55
      Related
      ENSMUSP00000145344.2, ENSMUST00000203578.3
      Conserved Domains (1) summary
      cl05433
      Location:1 → 76
      ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)

    3. NM_026552.3 → NP_080828.1  actin-related protein 2/3 complex subunit 4 isoform 1

      See identical proteins and their annotated locations for NP_080828.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC155287, AK017993, AK133626
      Consensus CDS
      CCDS20417.1
      UniProtKB/Swiss-Prot
      P59999, Q3UWV4
      UniProtKB/TrEMBL
      Q9D3C4
      Related
      ENSMUSP00000114839.2, ENSMUST00000156898.5
      Conserved Domains (1) summary
      pfam05856
      Location:1 → 166
      ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      113355074..113367408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59999.3 GenPept UniProtKB/Swiss-Prot:P59999

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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