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    Efcab7 EF-hand calcium binding domain 7 [ Mus musculus (house mouse) ]

    Gene ID: 230500, updated on 9-Dec-2024

    Summary

    Official Symbol
    Efcab7provided by MGI
    Official Full Name
    EF-hand calcium binding domain 7provided by MGI
    Primary source
    MGI:MGI:2385199
    See related
    Ensembl:ENSMUSG00000073791 AllianceGenome:MGI:2385199
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1799
    Summary
    Predicted to enable calcium ion binding activity. Involved in several processes, including positive regulation of protein localization; positive regulation of transcription by RNA polymerase II; and protein localization to motile cilium. Located in ciliary membrane and cytoplasmic side of plasma membrane. Part of plasma membrane protein complex. Is expressed in skin. Orthologous to human EFCAB7 (EF-hand calcium binding domain 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 2.9), testis adult (RPKM 2.1) and 17 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Efcab7 in Genome Data Viewer
    Location:
    4 C6; 4 45.71 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (99717440..99769985)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (99829445..99912788)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6192 Neighboring gene STARR-seq mESC enhancer starr_10875 Neighboring gene ALG6 alpha-1,3-glucosyltransferase Neighboring gene integrin beta 3 binding protein (beta3-endonexin) Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:99495752-99496005 Neighboring gene STARR-positive B cell enhancer ABC_E6193 Neighboring gene predicted gene, 26425 Neighboring gene phosphoglucomutase 1 Neighboring gene predicted gene, 35701

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Clone Names

    • MGC28352, MGC118010

    General protein information

    Preferred Names
    EF-hand calcium-binding domain-containing protein 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145549.2NP_663524.1  EF-hand calcium-binding domain-containing protein 7

      See identical proteins and their annotated locations for NP_663524.1

      Status: VALIDATED

      Source sequence(s)
      BX324127, CR536609, CU326395, MF597759
      UniProtKB/Swiss-Prot
      Q3UQS0, Q5DTU8, Q8VDY4
      Related
      ENSMUSP00000118989.4, ENSMUST00000136874.4
      Conserved Domains (2) summary
      COG5126
      Location:55168
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cl08302
      Location:407467
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      99717440..99769985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164002.1XP_036019895.1  EF-hand calcium-binding domain-containing protein 7 isoform X1

      Conserved Domains (2) summary
      COG5126
      Location:92205
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cl08302
      Location:444504
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    2. XM_036164007.1XP_036019900.1  EF-hand calcium-binding domain-containing protein 7 isoform X3

      Conserved Domains (2) summary
      COG5126
      Location:92205
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cl08302
      Location:360420
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    3. XM_036164006.1XP_036019899.1  EF-hand calcium-binding domain-containing protein 7 isoform X2

      UniProtKB/Swiss-Prot
      Q3UQS0, Q5DTU8, Q8VDY4
      Related
      ENSMUSP00000159398.2, ENSMUST00000239516.1
      Conserved Domains (2) summary
      COG5126
      Location:55168
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cl08302
      Location:407467
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    4. XM_036164003.1XP_036019896.1  EF-hand calcium-binding domain-containing protein 7 isoform X2

      UniProtKB/Swiss-Prot
      Q3UQS0, Q5DTU8, Q8VDY4
      Conserved Domains (2) summary
      COG5126
      Location:55168
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cl08302
      Location:407467
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    5. XM_036164004.1XP_036019897.1  EF-hand calcium-binding domain-containing protein 7 isoform X2

      UniProtKB/Swiss-Prot
      Q3UQS0, Q5DTU8, Q8VDY4
      Conserved Domains (2) summary
      COG5126
      Location:55168
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cl08302
      Location:407467
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    6. XM_036164008.1XP_036019901.1  EF-hand calcium-binding domain-containing protein 7 isoform X4

      UniProtKB/TrEMBL
      A2CEK1, Q2M1K0
      Conserved Domains (1) summary
      cl08302
      Location:270330
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    7. XM_036164005.1XP_036019898.1  EF-hand calcium-binding domain-containing protein 7 isoform X2

      UniProtKB/Swiss-Prot
      Q3UQS0, Q5DTU8, Q8VDY4
      Conserved Domains (2) summary
      COG5126
      Location:55168
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cl08302
      Location:407467
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    8. XM_036164009.1XP_036019902.1  EF-hand calcium-binding domain-containing protein 7 isoform X4

      UniProtKB/TrEMBL
      A2CEK1, Q2M1K0
      Conserved Domains (1) summary
      cl08302
      Location:270330
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    9. XM_036164010.1XP_036019903.1  EF-hand calcium-binding domain-containing protein 7 isoform X4

      UniProtKB/TrEMBL
      A2CEK1, Q2M1K0
      Conserved Domains (1) summary
      cl08302
      Location:270330
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RNA

    1. XR_004941864.1 RNA Sequence