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    Pkig protein kinase inhibitor, gamma [ Mus musculus (house mouse) ]

    Gene ID: 18769, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pkigprovided by MGI
    Official Full Name
    protein kinase inhibitor, gammaprovided by MGI
    Primary source
    MGI:MGI:1343086
    See related
    Ensembl:ENSMUSG00000035268 AllianceGenome:MGI:1343086
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PKIgamma
    Summary
    Enables cAMP-dependent protein kinase inhibitor activity. Acts upstream of or within negative regulation of protein import into nucleus; negative regulation of protein kinase activity; and negative regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; tongue; and vertebral axis musculature. Orthologous to human PKIG (cAMP-dependent protein kinase inhibitor gamma). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Ubiquitous expression in testis adult (RPKM 82.9), heart adult (RPKM 72.2) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pkig in Genome Data Viewer
    Location:
    2 H3; 2 84.4 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163500306..163568078)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163658211..163726158)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2057 Neighboring gene tocopherol (alpha) transfer protein-like Neighboring gene RIKEN cDNA 0610039K10 gene Neighboring gene serine incorporator 3 Neighboring gene STARR-positive B cell enhancer ABC_E10159 Neighboring gene STARR-positive B cell enhancer ABC_E9208 Neighboring gene STARR-positive B cell enhancer ABC_E819 Neighboring gene STARR-seq mESC enhancer starr_06314 Neighboring gene STARR-positive B cell enhancer ABC_E2058 Neighboring gene predicted gene 16316 Neighboring gene adenosine deaminase intronic regulatory elements Neighboring gene adenosine deaminase upstream regulatory elements Neighboring gene adenosine deaminase Neighboring gene cellular communication network factor 5 Neighboring gene potassium channel, subfamily K, member 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (3) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    cAMP-dependent protein kinase inhibitor gamma

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039390.3NP_001034479.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      See identical proteins and their annotated locations for NP_001034479.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 4. Variants 1-5 and 7-19 all encode the same isoform (1).
      Source sequence(s)
      AL591490
      Consensus CDS
      CCDS17014.1
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
      Related
      ENSMUSP00000096704.3, ENSMUST00000099105.9
      Conserved Domains (1) summary
      pfam02827
      Location:270
      PKI; cAMP-dependent protein kinase inhibitor
    2. NM_001039391.2NP_001034480.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      See identical proteins and their annotated locations for NP_001034480.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 4. Variants 1-5 and 7-19 all encode the same isoform (1).
      Source sequence(s)
      AK164716, BY343638, BY617655, CJ051558
      Consensus CDS
      CCDS17014.1
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
      Related
      ENSMUSP00000068344.7, ENSMUST00000064703.13
      Conserved Domains (1) summary
      pfam02827
      Location:270
      PKI; cAMP-dependent protein kinase inhibitor
    3. NM_001164053.2NP_001157525.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      See identical proteins and their annotated locations for NP_001157525.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longer isoform (1). Variants 1-5 and 7-19 all encode the same isoform (1).
      Source sequence(s)
      AL591490
      Consensus CDS
      CCDS17014.1
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
      Related
      ENSMUSP00000120145.2, ENSMUST00000126182.8
      Conserved Domains (1) summary
      pfam02827
      Location:270
      PKI; cAMP-dependent protein kinase inhibitor
    4. NM_001164055.1NP_001157527.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      See identical proteins and their annotated locations for NP_001157527.1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      Consensus CDS
      CCDS17014.1
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
      Related
      ENSMUSP00000126223.2, ENSMUST00000164399.8
      Conserved Domains (1) summary
      pfam02827
      Location:270
      PKI; cAMP-dependent protein kinase inhibitor
    5. NM_001277096.1NP_001264025.1  cAMP-dependent protein kinase inhibitor gamma isoform 2

      See identical proteins and their annotated locations for NP_001264025.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 4. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL591490
      UniProtKB/TrEMBL
      B7ZC22
      Conserved Domains (1) summary
      pfam02827
      Location:269
      PKI; cAMP-dependent protein kinase inhibitor
    6. NM_001420659.1NP_001407588.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
    7. NM_001420660.1NP_001407589.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
    8. NM_001420661.1NP_001407590.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
    9. NM_001420662.1NP_001407591.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
      Related
      ENSMUSP00000120355.2, ENSMUST00000131228.8
    10. NM_001420663.1NP_001407592.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
    11. NM_001420664.1NP_001407593.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
    12. NM_001420665.1NP_001407594.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
    13. NM_001420666.1NP_001407595.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
    14. NM_001420668.1NP_001407597.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
    15. NM_001420669.1NP_001407598.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
    16. NM_001420670.1NP_001407599.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
    17. NM_001420671.1NP_001407600.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
    18. NM_001420672.1NP_001407601.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
    19. NM_001420673.1NP_001407602.1  cAMP-dependent protein kinase inhibitor gamma isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL591490
    20. NM_001420674.1NP_001407603.1  cAMP-dependent protein kinase inhibitor gamma isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/TrEMBL
      B7ZC21
      Related
      ENSMUST00000147385.8
    21. NM_001420675.1NP_001407604.1  cAMP-dependent protein kinase inhibitor gamma isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/TrEMBL
      B7ZC21
    22. NM_001420676.1NP_001407605.1  cAMP-dependent protein kinase inhibitor gamma isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL591490
      UniProtKB/TrEMBL
      B7ZC21
    23. NM_011106.3NP_035236.1  cAMP-dependent protein kinase inhibitor gamma isoform 1

      See identical proteins and their annotated locations for NP_035236.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, compared to variant 4. Variants 1-5 and 7-19 all encode the same isoform (1).
      Source sequence(s)
      AL591490
      Consensus CDS
      CCDS17014.1
      UniProtKB/Swiss-Prot
      O70139
      UniProtKB/TrEMBL
      B7ZC22, Q3TP50
      Related
      ENSMUSP00000105027.3, ENSMUST00000109400.3
      Conserved Domains (1) summary
      pfam02827
      Location:270
      PKI; cAMP-dependent protein kinase inhibitor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      163500306..163568078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)