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    Adarb1 adenosine deaminase, RNA-specific, B1 [ Mus musculus (house mouse) ]

    Gene ID: 110532, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adarb1provided by MGI
    Official Full Name
    adenosine deaminase, RNA-specific, B1provided by MGI
    Primary source
    MGI:MGI:891999
    See related
    Ensembl:ENSMUSG00000020262 AllianceGenome:MGI:891999
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Red1; Adar2; D10Bwg0447e; 1700057H01Rik
    Summary
    This gene encodes a double-stranded-RNA-specific adenosine deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in cerebellum adult (RPKM 24.4), frontal lobe adult (RPKM 19.8) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Adarb1 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (77126561..77254125, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (77290727..77418292, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40703 Neighboring gene predicted gene 10941 Neighboring gene protein O-fucosyltransferase 2 Neighboring gene predicted gene, 17769 Neighboring gene predicted gene, 51791

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded RNA adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded RNA adenosine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded RNA adenosine deaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tRNA-specific adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in RNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in adenosine to inosine editing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenosine to inosine editing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within adenosine to inosine editing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adenosine to inosine editing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in base conversion or substitution editing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within facial nerve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hypoglossal nerve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within innervation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within motor behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within motor neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within neuromuscular process controlling posture IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral genome replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within spinal cord ventral commissure morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    double-stranded RNA-specific editase 1
    Names
    RNA-editing deaminase 1
    RNA-editing enzyme 1
    dsRNA adenosine deaminase
    NP_001020008.1
    NP_001020009.1
    NP_570965.2
    XP_006513125.1
    XP_006513126.1
    XP_006513127.1
    XP_030100683.1
    XP_036011393.1
    XP_036011394.1
    XP_036011395.1
    XP_036011396.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024837.2NP_001020008.1  double-stranded RNA-specific editase 1 isoform 2

      See identical proteins and their annotated locations for NP_001020008.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate, in-frame donor splice site at one of the internal coding exons, compared to transcript variant 1. This results in a longer isoform (2) containing a 10 aa segment that is missing in isoform 1.
      Source sequence(s)
      AF403107, BB622419, BC030049, BC040200
      Consensus CDS
      CCDS35948.1
      UniProtKB/Swiss-Prot
      Q3UHM7, Q8K3X1, Q91ZS6, Q91ZS7, Q91ZS8, Q91ZS9, Q99MU8
      Related
      ENSMUSP00000095976.3, ENSMUST00000098374.9
      Conserved Domains (3) summary
      smart00552
      Location:322708
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd19895
      Location:75146
      DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
      cd19898
      Location:232301
      DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    2. NM_001024838.2NP_001020009.1  double-stranded RNA-specific editase 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AK141777, AK164931, BC030049, BC040200, BY281644
      Conserved Domains (3) summary
      smart00552
      Location:316692
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd19895
      Location:69140
      DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
      cd19898
      Location:226295
      DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    3. NM_130895.3NP_570965.2  double-stranded RNA-specific editase 1 isoform 1

      See identical proteins and their annotated locations for NP_570965.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1).
      Source sequence(s)
      AF291049, AF403107, BB622419, BC030049, BC040200
      Consensus CDS
      CCDS35949.1
      UniProtKB/Swiss-Prot
      Q91ZS8
      Related
      ENSMUSP00000020496.8, ENSMUST00000020496.14
      Conserved Domains (3) summary
      smart00552
      Location:322698
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd19895
      Location:75146
      DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
      cd19898
      Location:232301
      DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

    RNA

    1. NR_004429.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate, in-frame donor splice site at one of the internal coding exons, and results from an auto RNA editing event (AA->AI) that creates a novel acceptor splice site, splicing to which inserts 47 nt into the coding region, compared to transcript variant 1. This causes a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense-mediated mRNA decay (NMD). According to PMIDs:12459255 and 16382140, the RNA editing_induced_alternative splicing is observed at a frequency of 80% in mouse and serves to regulate Adarb1 protein expression and activity in vivo.
      Source sequence(s)
      AF403109, BB622419, BC030049, BC040200
      Related
      ENSMUST00000144547.8
    2. NR_021486.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) results from an auto RNA editing event (AA->AI) that creates a novel acceptor splice site, splicing to which inserts 47 nt into the coding region, compared to transcript variant 1. This causes a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense-mediated mRNA decay (NMD). According to PMIDs:12459255 and 16382140, the RNA editing_induced_alternative splicing is observed at a frequency of 80% in mouse and serves to regulate Adarb1 protein expression and activity in vivo.
      Source sequence(s)
      AF403108, BC030049, BC040200, CJ115965
      Related
      ENSMUST00000105404.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      77126561..77254125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513064.3XP_006513127.1  double-stranded RNA-specific editase 1 isoform X4

      Conserved Domains (3) summary
      smart00552
      Location:316702
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd19895
      Location:69140
      DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
      cd19898
      Location:226295
      DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    2. XM_036155500.1XP_036011393.1  double-stranded RNA-specific editase 1 isoform X3

      UniProtKB/Swiss-Prot
      Q3UHM7, Q8K3X1, Q91ZS6, Q91ZS7, Q91ZS8, Q91ZS9, Q99MU8
      Conserved Domains (3) summary
      smart00552
      Location:322708
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd19895
      Location:75146
      DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
      cd19898
      Location:232301
      DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    3. XM_036155501.1XP_036011394.1  double-stranded RNA-specific editase 1 isoform X3

      UniProtKB/Swiss-Prot
      Q3UHM7, Q8K3X1, Q91ZS6, Q91ZS7, Q91ZS8, Q91ZS9, Q99MU8
      Conserved Domains (3) summary
      smart00552
      Location:322708
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd19895
      Location:75146
      DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
      cd19898
      Location:232301
      DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    4. XM_030244823.2XP_030100683.1  double-stranded RNA-specific editase 1 isoform X3

      UniProtKB/Swiss-Prot
      Q3UHM7, Q8K3X1, Q91ZS6, Q91ZS7, Q91ZS8, Q91ZS9, Q99MU8
      Conserved Domains (3) summary
      smart00552
      Location:322708
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd19895
      Location:75146
      DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
      cd19898
      Location:232301
      DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    5. XM_006513063.4XP_006513126.1  double-stranded RNA-specific editase 1 isoform X2

      Conserved Domains (3) summary
      smart00552
      Location:386762
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd19895
      Location:139210
      DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
      cd19898
      Location:296365
      DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    6. XM_006513062.4XP_006513125.1  double-stranded RNA-specific editase 1 isoform X1

      Conserved Domains (3) summary
      smart00552
      Location:386772
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd19895
      Location:139210
      DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
      cd19898
      Location:296365
      DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    7. XM_036155503.1XP_036011396.1  double-stranded RNA-specific editase 1 isoform X4

      Conserved Domains (3) summary
      smart00552
      Location:316702
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd19895
      Location:69140
      DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
      cd19898
      Location:226295
      DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    8. XM_036155502.1XP_036011395.1  double-stranded RNA-specific editase 1 isoform X3

      UniProtKB/Swiss-Prot
      Q3UHM7, Q8K3X1, Q91ZS6, Q91ZS7, Q91ZS8, Q91ZS9, Q99MU8
      Conserved Domains (3) summary
      smart00552
      Location:322708
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd19895
      Location:75146
      DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
      cd19898
      Location:232301
      DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024839.1: Suppressed sequence

      Description
      NM_001024839.1: This RefSeq, based on a downstream AUG, was permanently suppressed because use of the in-frame upstream AUG, with a strong Kozak signal, would render the transcript susceptible to nonsense-mediated decay.
    2. NM_001024840.1: Suppressed sequence

      Description
      NM_001024840.1: This RefSeq, based on a downstream AUG, was permanently suppressed because use of the in-frame upstream AUG, with a strong Kozak signal, would render the transcript susceptible to nonsense-mediated decay.