Atp6v0e ATPase, H+ transporting, lysosomal V0 subunit E [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp6v0eprovided by MGI
Official Full Name: ATPase, H+ transporting, lysosomal V0 subunit Eprovided by MGI
Primary source: MGI:MGI:1328318
See related: Ensembl:ENSMUSG00000015575 AllianceGenome:MGI:1328318
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: M9.2; Atp6k; Atp6v0e1
Summary: Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Part of proton-transporting V-type ATPase complex. Is expressed in several structures, including alimentary system; cranium; heart; nervous system; and sensory organ. Orthologous to human ATP6V0E1 (ATPase H+ transporting V0 subunit e1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 163.1), kidney adult (RPKM 139.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 13.46 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (26895370..26918621)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (26676396..26699647)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A cDNA encoding a novel putative neuron-specific isoform of vacuolar proton-translocating ATPase (V-ATPase), NM9.2, was isolated from rat and mouse.
Title: A novel putative M9.2 isoform of V-ATPase expressed in the nervous system.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224384

AI553519 (e-PCR)
- UniSTS:166041

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
enables proton-transporting ATPase activity, rotational mechanism	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proton transmembrane transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed
part_of proton-transporting V-type ATPase complex	IDA Inferred from Direct Assay more info	PubMed
part_of proton-transporting V-type ATPase, V0 domain	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: V-type proton ATPase subunit e 1

Names: ATPase, H+ transporting lysosomal (vacuolar proton pump), 9.2 kDa; ATPase, H+ transporting, V0 subunit e; ATPase, H+ transporting, lysosomal 9kD V0 subunit E; V-ATPase subunit e 1; lysosomal 9kDa; vacuolar proton pump subunit e 1

NP_079548.1

EC 7.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.