Wdr46 WD repeat domain 46 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr46provided by MGI
Official Full Name: WD repeat domain 46provided by MGI
Primary source: MGI:MGI:1931871
See related: Ensembl:ENSMUSG00000024312 AllianceGenome:MGI:1931871
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bing4; 2310007I04Rik
Summary: Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; liver; and retina. Orthologous to human WDR46 (WD repeat domain 46). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 12.7), liver E14.5 (RPKM 12.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34159608..34168669)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (33940634..33949695)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AF082504 (e-PCR)
- UniSTS:163585

RH126371 (e-PCR)
- UniSTS:163079

C78559 (e-PCR)
- UniSTS:181003

Bing4 (e-PCR), detects polymorphism
- UniSTS:463403

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: WD repeat-containing protein 46

Names: WD repeat-containing protein BING4; putative WD repeat domain 46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020603.2 → NP_065628.1 WD repeat-containing protein 46

See identical proteins and their annotated locations for NP_065628.1

Status: PROVISIONAL

Source sequence(s)

BC046977

Consensus CDS

CCDS28637.1

UniProtKB/Swiss-Prot

Q9Z0H1

UniProtKB/TrEMBL

A0A068BFS0

Related

ENSMUSP00000025170.10, ENSMUST00000025170.11

Conserved Domains (4) summary

smart01033
Location:439 → 517

BING4CT; BING4CT (NUC141) domain

COG2319
Location:202 → 389

WD40; WD40 repeat [General function prediction only]

sd00039
Location:198 → 234

7WD40; WD40 repeat [structural motif]

cl02567
Location:238 → 456

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

34159608..34168669

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524697.2 → XP_006524760.1 WD repeat-containing protein 46 isoform X1

See identical proteins and their annotated locations for XP_006524760.1

UniProtKB/TrEMBL

A0A068BFS0

Conserved Domains (4) summary

smart01033
Location:453 → 531

BING4CT; BING4CT (NUC141) domain

TIGR02223
Location:32 → 142

ftsN; cell division protein FtsN

sd00039
Location:212 → 248

7WD40; WD40 repeat [structural motif]

cl29593
Location:252 → 470

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...