Slc27a6 solute carrier family 27 (fatty acid transporter), member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc27a6provided by MGI
Official Full Name: solute carrier family 27 (fatty acid transporter), member 6provided by MGI
Primary source: MGI:MGI:3036230
See related: Ensembl:ENSMUSG00000024600 AllianceGenome:MGI:3036230
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FATP6; FACVL2; FATP-6; VLACS2; VLCSH1; VLCS-H1; mVLCS-H1; 4732438L20Rik
Summary: Enables very long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid import into cell and long-chain fatty acid metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Is expressed in several structures, including genitourinary system; integumental system; nervous system; nose; and respiratory system. Orthologous to human SLC27A6 (solute carrier family 27 member 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in placenta adult (RPKM 5.5), testis adult (RPKM 2.2) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 D3; 18 33.71 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (58689312..58745941)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (58556240..58612869)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased placental FATP6 promotes fatty acid transport and contributes to excess lipid accumulation in the fetal liver in model of obesity in pregnancy.
Title: Increased placental fatty acid transporter 6 and binding protein 3 expression and fetal liver lipid accumulation in a mouse model of obesity in pregnancy.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1)

General gene information

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Markers

Slc27a6 (e-PCR), detects polymorphism
- UniSTS:527548

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arachidonate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid-CoA ligase activity	TAS Traceable Author Statement more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables oleate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables very long-chain fatty acid-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in long-chain fatty acid import into cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within long-chain fatty acid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in long-chain fatty acid transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: long-chain fatty acid transport protein 6

Names: arachidonate--CoA ligase; fatty acid transport protein 6; fatty-acid-coenzyme A ligase, very long-chain 2; long-chain-fatty-acid--CoA ligase; solute carrier family 27 member 6; very long-chain acyl-CoA synthetase homolog 1

NP_001074541.1

EC 6.2.1.15

EC 6.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081072.1 → NP_001074541.1 long-chain fatty acid transport protein 6

Status: PROVISIONAL

Source sequence(s)

AC102231, AC158924

Consensus CDS

CCDS37828.1

UniProtKB/Swiss-Prot

E9Q9W4

UniProtKB/TrEMBL

Q14C50

Related

ENSMUSP00000025500.7, ENSMUST00000025500.7

Conserved Domains (1) summary

cl17068
Location:75 → 609

AFD_class_I; Adenylate forming domain, Class I superfamily