Acot8 acyl-CoA thioesterase 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acot8provided by MGI
Official Full Name: acyl-CoA thioesterase 8provided by MGI
Primary source: MGI:MGI:2158201
See related: Ensembl:ENSMUSG00000017307 AllianceGenome:MGI:2158201
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pte1; PTE-1; PTE-2
Summary: Enables fatty acyl-CoA hydrolase activity. Acts upstream of or within acyl-CoA metabolic process. Located in peroxisome. Orthologous to human ACOT8 (acyl-CoA thioesterase 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 26.5), duodenum adult (RPKM 22.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 85.27 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (164634688..164662132, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (164792768..164820219, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACOT4 and ACOT8 are responsible for the termination of beta-oxidation of dicarboxylic acids of medium-chain length with the concomitant release of the corresponding free acids
Title: The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetoacetyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables choloyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables choloyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables fatty acyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acyl-CoA hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables hydroxymethylglutaryl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acyl-CoA hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables medium-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables medium-chain fatty acyl-CoA hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables succinyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acyl-CoA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in acyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in dicarboxylic acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in dicarboxylic acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of CD4 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of CD4 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in peroxisome fission	IEA Inferred from Electronic Annotation more info
involved_in peroxisome fission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in peroxisomal matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal matrix	IEA Inferred from Electronic Annotation more info
located_in peroxisomal matrix	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acyl-coenzyme A thioesterase 8

Names: choloyl-coenzyme A thioesterase; peroxisomal acyl-CoA thioesterase 1; peroxisomal acyl-CoA thioesterase 2; peroxisomal acyl-coenzyme A thioester hydrolase 1; peroxisomal long-chain acyl-CoA thioesterase 1

NP_001349685.1

EC 3.1.2.1

EC 3.1.2.11

EC 3.1.2.2

EC 3.1.2.27

EC 3.1.2.3

EC 3.1.2.5

NP_001349686.1

EC 3.1.2.1

EC 3.1.2.11

EC 3.1.2.2

EC 3.1.2.27

EC 3.1.2.3

EC 3.1.2.5

NP_573503.2

EC 3.1.2.1

EC 3.1.2.11

EC 3.1.2.2

EC 3.1.2.27

EC 3.1.2.3

EC 3.1.2.5

XP_006498892.1

EC 3.1.2.1

EC 3.1.2.11

EC 3.1.2.2

EC 3.1.2.27

EC 3.1.2.3

EC 3.1.2.5

XP_006498894.1

EC 3.1.2.1

EC 3.1.2.11

EC 3.1.2.2

EC 3.1.2.27

EC 3.1.2.3

EC 3.1.2.5

XP_011237620.1

EC 3.1.2.1

EC 3.1.2.11

EC 3.1.2.2

EC 3.1.2.27

EC 3.1.2.3

EC 3.1.2.5

XP_011237621.1

EC 3.1.2.1

EC 3.1.2.11

EC 3.1.2.2

EC 3.1.2.27

EC 3.1.2.3

EC 3.1.2.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362756.1 → NP_001349685.1 acyl-coenzyme A thioesterase 8 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK033724, AL591127

Consensus CDS

CCDS89580.1

UniProtKB/TrEMBL

Q8BZR4

Related

ENSMUSP00000017451.7, ENSMUST00000017451.7

Conserved Domains (1) summary

cl26120
Location:35 → 246

4HBT_3; Thioesterase-like superfamily
NM_001362757.1 → NP_001349686.1 acyl-coenzyme A thioesterase 8 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AL591127

Conserved Domains (1) summary

TIGR00189
Location:3 → 228

tesB; acyl-CoA thioesterase II
NM_133240.2 → NP_573503.2 acyl-coenzyme A thioesterase 8 isoform 1

See identical proteins and their annotated locations for NP_573503.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AI122325, AK151924, BB604985

Consensus CDS

CCDS17057.1

UniProtKB/Swiss-Prot

P58137, Q8VHM4

UniProtKB/TrEMBL

Q3U965

Related

ENSMUSP00000099383.5, ENSMUST00000103094.11

Conserved Domains (3) summary

cd03444
Location:206 → 309

Thioesterase_II_repeat1; Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP) ...

cd03445
Location:40 → 131

Thioesterase_II_repeat2; Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP) ...

TIGR00189
Location:35 → 310

tesB; acyl-CoA thioesterase II

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

164634688..164662132 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498831.5 → XP_006498894.1 acyl-coenzyme A thioesterase 8 isoform X4

Conserved Domains (1) summary

TIGR00189
Location:2 → 179

tesB; acyl-CoA thioesterase II
XM_006498829.2 → XP_006498892.1 acyl-coenzyme A thioesterase 8 isoform X2

Conserved Domains (1) summary

TIGR00189
Location:3 → 227

tesB; acyl-CoA thioesterase II
XM_011239318.4 → XP_011237620.1 acyl-coenzyme A thioesterase 8 isoform X1

Conserved Domains (1) summary

TIGR00189
Location:9 → 230

tesB; acyl-CoA thioesterase II
XM_011239319.2 → XP_011237621.1 acyl-coenzyme A thioesterase 8 isoform X3

Conserved Domains (1) summary

TIGR00189
Location:3 → 224

tesB; acyl-CoA thioesterase II