Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc2a2provided by MGI
Official Full Name: solute carrier family 2 (facilitated glucose transporter), member 2provided by MGI
Primary source: MGI:MGI:1095438
See related: Ensembl:ENSMUSG00000027690 AllianceGenome:MGI:1095438
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Glut2; Glut-2
Summary: Enables D-glucose transmembrane transporter activity and dehydroascorbic acid transmembrane transporter activity. Involved in D-glucose transmembrane transport; dehydroascorbic acid transport; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in several cellular components, including apical plasma membrane; brush border; and cell-cell junction. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; immune system; and liver and biliary system. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Fanconi-Bickel syndrome; glycogen storage disease; and type 2 diabetes mellitus. Orthologous to human SLC2A2 (solute carrier family 2 member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 50.7), liver E18 (RPKM 37.6) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A3; 3 12.19 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (28752052..28782510)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (28697903..28728361)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sema4D deficiency enhances glucose tolerance through GLUT2 retention in hepatocytes.
Title: Sema4D deficiency enhances glucose tolerance through GLUT2 retention in hepatocytes.
Normal beta-Cell Glut2 Expression Is not Required for Regulating Glucose-Stimulated Insulin Secretion and Systemic Glucose Homeostasis in Mice.
Title: Normal β-Cell Glut2 Expression Is not Required for Regulating Glucose-Stimulated Insulin Secretion and Systemic Glucose Homeostasis in Mice.
Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2.
Title: Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2.
GLUT2 expression by glial fibrillary acidic protein-positive tanycytes is required for promoting feeding-response to fasting.
Title: GLUT2 expression by glial fibrillary acidic protein-positive tanycytes is required for promoting feeding-response to fasting.
Loss of function of renal Glut2 reverses hyperglycaemia and normalises body weight in mouse models of diabetes and obesity.
Title: Loss of function of renal Glut2 reverses hyperglycaemia and normalises body weight in mouse models of diabetes and obesity.
The phosphatidylserine flippase beta-subunit Tmem30a is essential for normal insulin maturation and secretion.
Title: The phosphatidylserine flippase β-subunit Tmem30a is essential for normal insulin maturation and secretion.
Activation of AMPK pathway compromises Rab11 downregulation-mediated inhibition of Schwann cell proliferation in a Glut1 and Glut3-dependent manner.
Title: Activation of AMPK pathway compromises Rab11 downregulation-mediated inhibition of Schwann cell proliferation in a Glut1 and Glut3-dependent manner.
Estimating and interpreting nonlinear receptive field of sensory neural responses with deep neural network models.
Title: Estimating and interpreting nonlinear receptive field of sensory neural responses with deep neural network models.
Diabetes-induced hyperglycemia reduces the capability of ovarian follicle cells by down-regulating Glut2 expression.
Title: Changes in Expression of Follicular Glucose Transporters May Be Involved in Ovarian Function Impairment during Diabetic Hyperglycemia.
Glut2 expression in the nervous system is required for the control of cerebral blood flow in response to changes in blood glucose concentrations.
Title: Glucose transporter 2 mediates the hypoglycemia-induced increase in cerebral blood flow.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (3)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc2a2 (e-PCR), detects polymorphism
- UniSTS:144423

Slc2a2 (e-PCR), detects polymorphism
- UniSTS:532567

AI266973 (e-PCR)
- UniSTS:178817

PMC86965P1 (e-PCR)
- UniSTS:273567

D3Mit268 (e-PCR), detects polymorphism
- UniSTS:129696

Slc2a2 (e-PCR), detects polymorphism
- UniSTS:546002

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables D-glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables D-glucose transmembrane transporter activity	TAS Traceable Author Statement more info
enables dehydroascorbic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables dehydroascorbic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables fructose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables fructose transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables galactose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables galactose transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in D-glucose import	IBA Inferred from Biological aspect of Ancestor more info
involved_in D-glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within carbohydrate transport	TAS Traceable Author Statement more info
involved_in carbohydrate utilization	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fatty acid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in dehydroascorbic acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in dehydroascorbic acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dehydroascorbic acid transport	ISO Inferred from Sequence Orthology more info
involved_in fructose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in fructose transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in galactose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in galactose transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in brush border	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border	IDA Inferred from Direct Assay more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 2

Names: glucose transporter type 2, liver; liver-type glucose transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031197.2 → NP_112474.2 solute carrier family 2, facilitated glucose transporter member 2

See identical proteins and their annotated locations for NP_112474.2

Status: VALIDATED

Source sequence(s)

AI120520, AK005068, AK165430

Consensus CDS

CCDS50880.1

UniProtKB/Swiss-Prot

P14246, Q3TNA5, Q9DBA7

Related

ENSMUSP00000029240.8, ENSMUST00000029240.14

Conserved Domains (2) summary

cd06174
Location:90 → 484

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:14 → 498

Sugar_tr; Sugar (and other) transporter