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    Slc44a5 solute carrier family 44, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 242259, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc44a5provided by MGI
    Official Full Name
    solute carrier family 44, member 5provided by MGI
    Primary source
    MGI:MGI:3035141
    See related
    Ensembl:ENSMUSG00000028360 AllianceGenome:MGI:3035141
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm422
    Summary
    Predicted to enable choline transmembrane transporter activity. Predicted to be involved in choline transport and transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in brain; glossopharyngeal ganglion; lip; trachea; and ventral grey horn. Orthologous to human SLC44A5 (solute carrier family 44 member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 4.0), whole brain E14.5 (RPKM 3.7) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc44a5 in Genome Data Viewer
    Location:
    3 H3- H4; 3 78.82 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (153679056..153977384)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (153973436..154271747)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 45C Neighboring gene STARR-seq mESC enhancer starr_09325 Neighboring gene Rab geranylgeranyl transferase, b subunit Neighboring gene STARR-positive B cell enhancer ABC_E6148 Neighboring gene acyl-Coenzyme A dehydrogenase, medium chain Neighboring gene STARR-seq mESC enhancer starr_09326 Neighboring gene STARR-seq mESC enhancer starr_09327 Neighboring gene STARR-seq mESC enhancer starr_09328 Neighboring gene predicted gene, 40185 Neighboring gene STARR-seq mESC enhancer starr_09331 Neighboring gene predicted gene 3076 Neighboring gene STARR-seq mESC enhancer starr_09333 Neighboring gene predicted gene, 32399 Neighboring gene predicted gene, 40184 Neighboring gene expressed sequence AI606473 Neighboring gene LIM homeobox protein 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity. Catela C, et al. Elife, 2022 Mar 22. PMID 35315772, Free PMC Article
    2. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Cirilli M, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27746211
    3. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
    4. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables choline transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables choline transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in choline transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in choline transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    choline transporter-like protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081263.1 → NP_001074732.1  choline transporter-like protein 5

      See identical proteins and their annotated locations for NP_001074732.1

      Status: PROVISIONAL

      Source sequence(s)
      AC087184, AC119163
      Consensus CDS
      CCDS38679.1
      UniProtKB/Swiss-Prot
      Q5RJI2
      UniProtKB/TrEMBL
      A0A668KLB5
      Related
      ENSMUSP00000087394.6, ENSMUST00000089948.6
      Conserved Domains (1) summary
      pfam04515
      Location:341 → 680
      Choline_transpo; Plasma-membrane choline transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      153679056..153977384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501497.4 → XP_006501560.1  choline transporter-like protein 5 isoform X8

      See identical proteins and their annotated locations for XP_006501560.1

      UniProtKB/TrEMBL
      A0A668KLB5
      Conserved Domains (1) summary
      pfam04515
      Location:300 → 640
      Choline_transpo; Plasma-membrane choline transporter

    2. XM_006501489.5 → XP_006501552.1  choline transporter-like protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A668KLB5
      Conserved Domains (1) summary
      pfam04515
      Location:351 → 691
      Choline_transpo; Plasma-membrane choline transporter

    3. XM_006501488.5 → XP_006501551.1  choline transporter-like protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A668KLB5
      Conserved Domains (1) summary
      pfam04515
      Location:351 → 691
      Choline_transpo; Plasma-membrane choline transporter

    4. XM_006501494.4 → XP_006501557.1  choline transporter-like protein 5 isoform X6

      UniProtKB/TrEMBL
      A0A668KLB5
      Conserved Domains (1) summary
      pfam04515
      Location:351 → 686
      Choline_transpo; Plasma-membrane choline transporter

    5. XM_006501492.4 → XP_006501555.1  choline transporter-like protein 5 isoform X4

      UniProtKB/TrEMBL
      A0A668KLB5
      Conserved Domains (1) summary
      pfam04515
      Location:341 → 681
      Choline_transpo; Plasma-membrane choline transporter

    6. XM_006501490.5 → XP_006501553.1  choline transporter-like protein 5 isoform X3

      See identical proteins and their annotated locations for XP_006501553.1

      UniProtKB/TrEMBL
      A0A668KLB5
      Conserved Domains (1) summary
      pfam04515
      Location:346 → 686
      Choline_transpo; Plasma-membrane choline transporter

    7. XM_006501496.5 → XP_006501559.1  choline transporter-like protein 5 isoform X7

      See identical proteins and their annotated locations for XP_006501559.1

      UniProtKB/TrEMBL
      A0A668KLB5
      Conserved Domains (1) summary
      pfam04515
      Location:307 → 647
      Choline_transpo; Plasma-membrane choline transporter

    8. XM_006501493.4 → XP_006501556.1  choline transporter-like protein 5 isoform X5

      UniProtKB/TrEMBL
      A0A668KLB5
      Related
      ENSMUSP00000159268.2, ENSMUST00000239250.2
      Conserved Domains (1) summary
      pfam04515
      Location:336 → 676
      Choline_transpo; Plasma-membrane choline transporter

    9. XM_006501498.4 → XP_006501561.1  choline transporter-like protein 5 isoform X8

      See identical proteins and their annotated locations for XP_006501561.1

      UniProtKB/TrEMBL
      A0A668KLB5
      Conserved Domains (1) summary
      pfam04515
      Location:300 → 640
      Choline_transpo; Plasma-membrane choline transporter

    10. XM_006501495.4 → XP_006501558.1  choline transporter-like protein 5 isoform X7

      See identical proteins and their annotated locations for XP_006501558.1

      UniProtKB/TrEMBL
      A0A668KLB5
      Conserved Domains (1) summary
      pfam04515
      Location:307 → 647
      Choline_transpo; Plasma-membrane choline transporter

    11. XM_006501499.4 → XP_006501562.1  choline transporter-like protein 5 isoform X9

      See identical proteins and their annotated locations for XP_006501562.1

      UniProtKB/TrEMBL
      A0A668KLB5
      Conserved Domains (1) summary
      pfam04515
      Location:280 → 620
      Choline_transpo; Plasma-membrane choline transporter

    12. XM_006501500.4 → XP_006501563.1  choline transporter-like protein 5 isoform X9

      See identical proteins and their annotated locations for XP_006501563.1

      UniProtKB/TrEMBL
      A0A668KLB5
      Conserved Domains (1) summary
      pfam04515
      Location:280 → 620
      Choline_transpo; Plasma-membrane choline transporter

    13. XM_036163106.1 → XP_036018999.1  choline transporter-like protein 5 isoform X9

      UniProtKB/TrEMBL
      A0A668KLB5
      Conserved Domains (1) summary
      pfam04515
      Location:280 → 620
      Choline_transpo; Plasma-membrane choline transporter

    14. XM_006501501.4 → XP_006501564.1  choline transporter-like protein 5 isoform X9

      See identical proteins and their annotated locations for XP_006501564.1

      UniProtKB/TrEMBL
      A0A668KLB5
      Conserved Domains (1) summary
      pfam04515
      Location:280 → 620
      Choline_transpo; Plasma-membrane choline transporter

    15. XM_036163107.1 → XP_036019000.1  choline transporter-like protein 5 isoform X10

      UniProtKB/TrEMBL
      A0A668KLB5
      Conserved Domains (1) summary
      pfam04515
      Location:217 → 557
      Choline_transpo; Plasma-membrane choline transporter

    RNA

    1. XR_375525.5 RNA Sequence

    2. XR_375526.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RJI2.1 GenPept UniProtKB/Swiss-Prot:Q5RJI2

    Gene LinkOut

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